Search for dissertations about: "Chronic myeloid leukaemia"

Showing result 1 - 5 of 12 swedish dissertations containing the words Chronic myeloid leukaemia.

2. 1. Clinical and Immunological Studies in Chronic Myeloid Leukaemia

   Author : Stina Söderlund; Ulla Olsson-Strömberg; Angelica Loskog; Satu Mustjoki; Dragana Milojkovic; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic myeloid leukaemia; accelerated phase; blast crisis; tyrosine kinase inhibitor; immunology; myeloid-derived suppressor cells; cytokines; proteomics; TKI discontinuation; population-based;

   Abstract : Chronic myeloid leukaemia (CML) is characterised by the constitutively active tyrosine kinase BCR-ABL. Standard treatment with tyrosine kinase inhibitors (TKI) in the chronic phase (CP) of CML conveys excellent long-term prognosis but is associated with side effects and costs. READ MORE

4. 2. Clinical and Genetic studies in Chronic Myeloid Leukaemia

   Author : Hjalmar Flygt; Ulla Olsson Strömberg; Stina Söderlund; Lucia Cavelier; Jane Apperley; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; Chronic Myeloid Leukemia; Medicinsk vetenskap; Medical Science;

   Abstract : This thesis explores strategies to enhance deep molecular response (DMR) rates and treatment-free remission (TFR) eligibility in chronic myeloid leukaemia (CML), investigates factors linked to treatment milestone failures, describes tyrosine kinase inhibitor (TKI) discontinuation outcomes in a population-based cohort, and examines TFR probabilities after a second TKI discontinuation. In paper I we examined data from the Swedish CML registry on 128 CML patients in chronic phase with a reported TKI discontinuation of ≥1 month due to DMR. READ MORE

5. 3. Studies of leukotriene C4 synthase expression and regulation in chronic myeloid leukaemia

   Author : Cecilia Roos; Susanne Tornhamre; Anita Sjölander; Karlstads universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; leukotriene C4 synthase; chronic myeloid leukaemia; p210 BCR-ABL; myelopoiesis; imatinib mesylate; Cell biology; Cellbiologi; Biomedical Sciences; Biomedicinsk vetenskap;

   Abstract : Leukotriene (LT) C4 is generated through conjugation of LTA4 with glutathione by the actions of leukotriene C4 synthase (LTC4S). This biologically potent mediator of asthma and inflammation has also been suggested to play a regulatory role in human myelopoiesis and is overproduced by blood and bone marrow cells from patients with chronic myeloid leukaemia (CML). READ MORE

6. 4. Modelling the evolution of treatment-induced resistance in Ph+ leukaemias

   Author : Jonathan Lindström; Ran Friedman; Arne Traulsen; Linnéuniversitetet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic myeloid leukaemia; Stochastic modelling; Tyrosine kinase inhibitor; Drug resistance; Clonal evolution; Biomedical Sciences; Biomedicinsk vetenskap; Medicinsk kemi; Medical Chemistry;

   Abstract : Targeted therapies are a mainstay of modern cancer treatments. Rather than harming rapidly dividing cells in general, targeted therapies work by directly interfering with oncogenic molecular pathways present in a tumour. Consequently, a targeted therapy typically has less severe side effects. READ MORE

7. 5. Systemic lupus erythematosus (SLE) and cancer : epidemiological and immunohistochemical studies on SLE patients with malignant lymphoma or myeloid leukaemia

   Author : Björn Lövström; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Malignancy as a cause of death was reported in occasional SLE patients, but the question whether patients with SLE have an increased risk of developing cancer compared to the general population has remained unanswered. To address this question, we created a national Swedish SLE cohort from the Hospital Discharge Register where all patients with an SLE diagnosis between 1964 and 1994 were included. READ MORE