Search for dissertations about: "Chylomicron"

Showing result 6 - 10 of 14 swedish dissertations containing the word Chylomicron.

2. 6. Early steps of Eicosanoid precursor absorption and tissue distribution

   Author : Tor Melin; Lund Medicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipids; mebran; steroider; Lipider; steroids; membranes; Gastro-enterology; Gastroenterologi;

   Abstract : Eicosanoids are important for a wide range of physiological and pathophysiological processes.How their essential fatty acid precursors are absorbed and tissue distributed is not well charactherized. When given orally to rats, arachidonic acid (20:4) was retained in the small intestine to a larger extent than linoleic acid (18:2). READ MORE

4. 7. Postprandial lipaemia and its relation to premature atherosclerosis in middle-aged men

   Author : Susanna Boquist; Karolinska Institutet; Karolinska Institutet; []
   Keywords : alimentary lipaemia; atherosclerosis; atorvastatin; coronary heart disease; intima-media thickness; triglyceride-rich lipoproteins;

   Abstract : The present research programme was set up to investigate whether pertubations of the metabolism of postprandial triglyceride-rich lipoproteins (TRLs) are related to premature atherosclerosis and to determine if treatment with a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (atorvastatin) improves deranged alimentary lipaemia in postinfarction patients with combined hyperlipidaemia. The relation between plasma insulin and alimentary lipaemia was investigated as well. READ MORE

5. 8. Proteomic profiling of osteoarthritis. A computational approach to biomarker discovery

   Author : Martin Rydén; Lund Ortopedi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Computational Biology; Bioinformatics for Proteomics;

   Abstract : Understanding the molecular mechanisms of osteoarthritis (OA) is critical for early diagnosis and effective treatment. OA is a leading cause of disability and poses an increasing burden on healthcare systems, particularly with an aging global population. READ MORE

6. 9. Interaction of Triglyceride-rich Lipoproteins with Platelets and Vitamin K-dependent Coagulation Factors

   Author : Ning Xu; Avdelningen för klinisk kemi och farmakologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Triglycerides.; Prothrombin; Protein S; Protein C; Platelets; Phospholipids; Metabolism; Lipoproteins; Lipids; Endocytosis; Electron microscopy; Cytochemistry; Coronary heart disease; Blood coagulation factors; Arachidonic acid; Atherosclerosis; Clinical chemistry; Klinisk kemi; Haematology; extracellular fluids; Hematologi; extracellulära vätskor;

   Abstract : 1. During incubation of platelets with 3H-arachidonic acid (20:4, n-6) and 14C-cholesterol doubly labelled and colloidal gold labelled chylomicrons (CMs) and chylomicron remnants (CMRs) CMs were taken up more efficiently than CMRs. Addition of unlabelled CMs, VLDLs, LDLs and HDLs decreased the uptake of labelled CMs. READ MORE

7. 10. Fatty acids induce potentially atherogenic changes in extracellular matrix proteoglycans

   Author : Mariam Rodríguez-Lee; Göteborgs universitet; []
   Keywords : proteoglycans; glycosaminoglycans; fatty acids; smooth muscle cells; hepatocytes; LDL binding; remnant clearance; insulin resistance; type 2 diabetes;

   Abstract : Insulin resistance and type 2 diabetes (T2D) are associated with an increased prevalence of atherosclerotic cardiovascular disease (CVD). A key step in the initiation of atherogenesis is retention of low density lipoproteins (LDL) in the intima by chondroitin sulfate (CS)-rich proteoglycans (PG). READ MORE