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Showing result 1 - 5 of 63 swedish dissertations matching the above criteria.

  2. 1. Exploring the Ciprofloxacin Resistome

    Author : Linnéa Garoff; Diarmaid Hughes; Jesús Blázquez; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance; Experimental evolution; Ciprofloxacin; Escherichia coli; Mikrobiologi; Microbiology;

    Abstract : This thesis presents an exploration of the resistance evolution in Escherichia coli towards the antibiotic ciprofloxacin. High level ciprofloxacin resistance is typically acquired by an accumulation of mutations and plasmid borne genes reducing drug target binding, increasing drug efflux, and modifying the drug. READ MORE

  4. 2. Constraints on up-regulation of drug efflux in the evolution of ciprofloxacin resistance

    Author : Lisa Praski Alzrigat; Diarmaid Hughes; Fernando Baquero; Uppsala universitet; []
    Keywords : ciprofloxacin; antibiotic resistance; drug efflux; bacterial fitness; marR; acrR; marA; experimental evolution; Mikrobiologi; Microbiology;

    Abstract : The crucial role of antibiotics in modern medicine, in curing infections and enabling advanced medical procedures, is being threatened by the increasing frequency of resistant bacteria. Better understanding of the forces selecting resistance mutations could help develop strategies to optimize the use of antibiotics and slow the spread of resistance. READ MORE

  5. 3. Hazard assessment of ciprofloxacin, sulfamethoxazole and triclosan for marine periphyton : Ecotoxicology, Pollution Induced Community Tolerance and Co-Tolerance

    Author : Henrik Johansson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ecotoxicology; Antibioitcs; Antimicrobial agents; Ciprofloxacin; Sulfamethoxazole; Triclosan; Community ecotoxicology; Periphyton; Toxicant-induced succession; Pollution-Induced Community Tolerance PICT ;

    Abstract : Antibiotics and personal care products are used in large quantities and commonly detected in various environmental compartments. The two antibiotics, ciprofloxacin and sulfamethoxazole, and the personal care product triclosan are among the most commonly detected compounds in sewage treatment plants and aquatic environments. READ MORE

  6. 4. Experimental modulation and suppression of anti-allograft immune response

    Author : Öyvind Östraat; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; linomide; leflunomide; cyclophosphamide; mycophenolate mofetil; azathioprine; thalidomide; cyclosporin A; ciprofloxacin; flow cytometry; production; IL-2; Rat cardiac transplantation; allograft; Immunology; serology; transplantation; Immunologi; serologi;

    Abstract : Abstract The objective of this investigation was to characterise the immunomodulatory or immunosuppressive effects of single drug treatment and the potential synergistic or additive effects of combined treatment with the focus on ciprofloxacin, thalidomide, mycophenolate mofetil, azathioprine, cyclophosphamide or leflunomide added to cyclosporin A (CyA). A rat cardiac transplant model was used to study graft survival and the influence on lymphocytes was evaluated by in vitro tests. READ MORE

  7. 5. Evolution of Antibiotic Resistance

    Author : Franziska Pietsch; Diarmaid Hughes; Josep Casadesús; Uppsala universitet; []
    Keywords : ciprofloxacin; rifampicin; bacterial fitness; compensation; mutation rate; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Abstract : The emergence of antimicrobial resistance is a major global threat to modern medicine. The rapid dissemination of resistant pathogens and the associated loss of efficacy of many important drugs needs to be met with the development of new antibiotics and alternative treatment options. READ MORE