Search for dissertations about: "Circular permutant"

Found 2 swedish dissertations containing the words Circular permutant.

2. 1. Protein Folding, Binding and Evolution : PDZ domains and paralemmins as model systems

   Author : Greta Hultqvist; Per Jemth; Ruth Nussinov; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein folding; evolution; binding; allostery; Paralemmin; PDZ domain;

   Abstract : Proteins present at the synapse need to be multitasking in order to perform all vital functions in this limited space. In this thesis I have analyzed the function and evolution of such proteins, focusing on the PDZ domain and the paralemmin family. The PDZ domains bind to a wide variety of interaction partners. READ MORE

4. 2. Folding of the Ribosomal protein S6 : The role of sequence connectivity, overlapping foldons, and parallel pathways

   Author : Ellinor Haglund; Mikael Oliveberg; Neil Ferguson; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein folding; protein stability; two-state folding; S6; chevron plot; transition state; parallell pathways; foldon; two-channel landscape; protein engineering; H D-exchange; Biochemistry; Biokemi; Biochemistry; biokemi;

   Abstract : To investigate how protein folding is affected by sequence connectivity five topological variants of the ribosomal protein S6 were constructed through circular permutation.  In these constructs, the chain connectivity (i.e. the order of secondary-structure elements) is changed without changing the native-state topology. READ MORE