Search for dissertations about: "Cisplatin in-line cleavage oxaliplatin circular dichroism DENSPM polyamines siRNA pseudoknot RNA thermal melting anticancer active Pt II complex DNA"

Found 1 swedish dissertation containing the words Cisplatin in-line cleavage oxaliplatin circular dichroism DENSPM polyamines siRNA pseudoknot RNA thermal melting anticancer active Pt II complex DNA.

  2. 1. Cationic Interactions with Nucleic Acids With Focus on Anticancer Active Platinum(II) Complexes

    Author : Åse Sykfont Snygg; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; in-line cleavage; Cisplatin; oxaliplatin; circular dichroism; DENSPM; polyamines; siRNA; pseudoknot; RNA; thermal melting; anticancer active Pt II complex; DNA;

    Abstract : It is well documented that the antitumour activity of the Pt(II)-complex cisplatin, and similar anticancer active complexes, is a result of metalation of DNA, and thereby inhibition of cell proliferation. Since nucleic acids are polyanions at physiological pH, the rate of adduct formation with positively charged complex, as the hydrolyzed Pt(II) complexes studied in this work, is influenced by the ionic environment surrounding the polymer. READ MORE