Search for dissertations about: "Cisplatin"

Showing result 1 - 5 of 105 swedish dissertations containing the word Cisplatin.

  1. 1. Quantum Chemical Studies of Chemotherapeutic Drug Cisplatin Activation and Binding to DNA

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Johan Raber; David van der Spoel; Paolo Carloni; [2007]
    Keywords : Quantum chemistry; cisplatin; quantum chemistry; DNA; density functional theory; activation; JM118; substitution reaction; Platinum; guanine; adenine; cytostatic drug; aquation; anation; activation; Kvantkemi;

    Abstract : The serendipitous discovery of the potent cytotoxic properties of cisplatin brought about a revolution in the treatment of certain types of cancer, but almost fifty years later, there still remain unknown areas in the chemistry of cisplatin. There are questions regarding which form of the drug reaches its DNA target, or why certain DNA sequences are more preferred than others for reaction with cisplatin. READ MORE

  2. 2. Studies of radioactive cisplatin (191Pt) for tumour imaging and therapy

    University dissertation from Radiaiton Physics, Malmö University Hospital, SE-205 02 Malmö, Sweden

    Author : Johan Areberg; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytology; mice; in vitro; gamma camera; tumour imaging; platinum pharmacokinetics; cisplatin; radioactive; oncology; cancerology; Cytologi; onkologi; cancer;

    Abstract : A radioactive variant of the cytostatic agent cis-dichlorodiammineplatinum(II), cisplatin, was synthesised from 191PtCl4. The 191Pt-cisplatin was found to be a sterile product of high radionuclide, radiochemical and chemical purity. READ MORE

  3. 3. Pharmacokinetic and pharmacodynamic studies on cisplatin in mice and men

    University dissertation from Anders Johnsson MD, Dept of Oncology, University Hospital, S-21 85 Lund, Sweden

    Author : Anders Johnsson; [1996]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytologi; cancerology; oncology; Cytology; immunohistochemistry; nephrotoxicity; pharmacodynamics; pharmacokinetics; Cisplatin; DNA adducts; platinum; onkologi; cancer; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : Methodological tools for studies of the cytostatic agen cisplatin (CDDP) were explored and applied to elucidate various aspects of pharmacokinetics, drug distribution, chemomodulation and pharmacodynamics. An immunohistochemical assay for analysis of CDDP-DNA adducts, i.e. READ MORE

  4. 4. Advances in analytical methodologies for studies of the platinum metallome in malignant cells exposed to cisplatin

    University dissertation from Umeå : Kemiska Institutionen, Umeå universitet

    Author : Yvonne Nygren; Erik Björn; Knut Irgum; Bente Gammelgaard; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Method development; Metallome; Inductively coupled plasma mass spectrometry; Electrospray ionization mass spectrometry; Liquid chromatography; Hyphenation; Organic modifier; Cisplatin; Platinum; NATURAL SCIENCES Chemistry Analytical chemistry; NATURVETENSKAP Kemi Analytisk kemi; analytisk kemi; Analytical Chemistry;

    Abstract : The scientific progress about the important chemotherapeutic drug substance cisplatin (CDDP) and its function has often been rendered by data difficult to interpret, and still many questions about its mode of action remains to be clarified by the scientific community. However, studies of CDDP possess a high complexity due to; i) low intracellular concentration, ii) many potential biomolecule targets, iii) poor or unknown stability of the intact drug and its biomolecule adducts and iv) complex and varying sample matrices. READ MORE

  5. 5. Cisplatin, a platinum-containing antineoplastic drug: perspectives on analytical chemistry and prevention of ototoxicity

    University dissertation from Stockholm : Karolinska Institutet, Dept of Oncology-Pathology

    Author : Pernilla Videhult Pierre; Karolinska Institutet.; Karolinska Institutet.; [2010]

    Abstract : The platinum-containing drug cisplatin plays a key role in the curative and palliative treatment of many solid malignancies. Unfortunately, the treatment can lead to sensorineural hearing loss, which limits the use of the drug. READ MORE