Search for dissertations about: "Claes Wadelius"

Showing result 1 - 5 of 13 swedish dissertations containing the words Claes Wadelius.

  1. 1. Molecular studies of genes and mutations in families with genetic disorders

    Author : Claes Wadelius; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  2. 2. A Bioinformatics Study of Human Transcriptional Regulation

    Author : Adam Ameur; Jan Komorowski; Claes Wadelius; Philipp Bucher; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; microarray; ChIP-chip; ChIP-seq; transcription factor; histone modification; motif search; Bioinformatics; Bioinformatik;

    Abstract : Regulation of transcription is a central mechanism in all living cells that now can be investigated with high-throughput technologies. Data produced from such experiments give new insights to how transcription factors (TFs) coordinate the gene transcription and thereby regulate the amounts of proteins produced. READ MORE

  3. 3. Decoding the Structural Layer of Transcriptional Regulation : Computational Analyses of Chromatin and Chromosomal Aberrations

    Author : Robin Andersson; Jan Komorowski; Jan Dumanski; Claes Wadelius; Anders Krogh; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Chromatin; Nucleosome positioning; Histone modifications; Chromosomal aberrations; Transcriptional regulation; Array-CGH; Next generation sequencing; ChIP-chip; Bioinformatics; Bioinformatik; Bioinformatics; Bioinformatik;

    Abstract : Gene activity is regulated at two separate layers. Through structural and chemical properties of DNA – the primary layer of encoding – local signatures may enable, or disable, the binding of proteins or complexes of them with regulatory potential to the DNA. READ MORE

  4. 4. Rule-based Models of Transcriptional Regulation and Complex Diseases : Applications and Development

    Author : Susanne Bornelöv; Jan Komorowski; Claes Wadelius; Joanna Polanska; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; Histone modification; Transcription factor; Transcriptional regulation; Next-generation sequencing; Feature selection; Machine learning; Rule-based classification; Asthma; Allergy; Bioinformatik; Bioinformatics;

    Abstract : As we gain increased understanding of genetic disorders and gene regulation more focus has turned towards complex interactions. Combinations of genes or gene and environmental factors have been suggested to explain the missing heritability behind complex diseases. READ MORE

  5. 5. Genome-Wide Studies of Transcriptional Regulation in Human Liver Cells by High-throughput Sequencing

    Author : Madhusudhan Reddy Bysani; Claes Wadelius; Mattias Mannervik; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ChIP-seq; Transcription factors; Alcoholic steatohepatitis; Genome-wide; GWAS; SNPs;

    Abstract : The human genome contains slightly more than 20 000 genes that are expressed in a tissue specific manner. Transcription factors play a key role in gene regulation. By mapping the transcription factor binding sites genome-wide we can understand their role in different biological processes. READ MORE