Search for dissertations about: "Claes Wadelius"
Showing result 11 - 14 of 14 swedish dissertations containing the words Claes Wadelius.
-
11. From Single Gene to Whole Genome Studies of Human Transcription Regulation
Abstract : Transcriptional regulation largely determines which proteins and the protein levels that are found in a cell, and this is crucial in development, differentiation and responses to environmental stimuli. The major effectors of transcriptional regulation are a group of proteins known as transcription factors, which importance is supported by their frequent involvement in mendelian and complex diseases. READ MORE
-
12. Elucidation of complex diseases by machine learning
Abstract : Uncovering the interpretability of models for complex health-related problems is a crucial task that is often neglected in machine learning (ML). The amount of available data makes the problem even more complicated. READ MORE
-
13. Computational Modelling of Gene Regulation in Cancer : Coding the noncoding genome
Abstract : Technological advancements have enabled quantification of processes within and around us. The information stored within our body converts into petabytes of data. Processing and learning from such data requires comprehensive computational programs and software systems. READ MORE
-
14. Genome-Wide Studies of Transcriptional Regulation in Mammalian Cells
Abstract : The key to the complexity of higher organisms lies not in the number of protein coding genes they carry, but rather in the intrinsic complexity of the gene regulatory networks. The major effectors of transcriptional regulation are proteins called transcription factors, and in this thesis four papers describing genome-wide studies of seven such factors are presented, together with studies on components of the chromatin and transcriptome. READ MORE