Search for dissertations about: "Clara Cell Secretory Protein"

Found 3 swedish dissertations containing the words Clara Cell Secretory Protein.

  2. 1. Regulation and function of the Clara cell secretory protein

    Author : Magnus Nord; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Lung Clara cells Uteroglobin Polychlorinated biphenyls Rat Mouse Hu-man Fetal development Glucocorticoids Cells; cultured Gene expression regulation CEBP Calcium Protein conformation Computer simulation Mutagenesis; site-directedCalcium binding pr;

    Abstract : The Clara cell secretory protein (CCSP; also known as Polychlorinated Biphenyl-binding protein (PCB-BP) or Uteroglobin) is specifically produced and secreted into the distal airway lumen by the non-ciliated Clara cell. It is a low molecular weight homodimeric protein and binds certain metabolites of PCBs as well as progestins and calcium. READ MORE

  4. 2. Transcriptional regulation of differentiation markers in the distal lung epithelium : a role for C/EBP factors

    Author : Tobias Cassel; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Lung; C EBP; Cellular Differentiation; Clara Cell Secretory Protein; Development; Gene Expression; Transcriptional Regulation; CYP21B1; Promoter; Synergism; Nkx2.1;

    Abstract : Late lung development is characterised by extensive cellular differentiation, resulting in a variety of specialised epithelial cell types. Although much is known of the extracellular signalling involved in lung morphogenesis, less is currently known of the intracellular developmental mechanisms that govern cellular differentiation. READ MORE

  5. 3. C/EBP transcription factors in lung cellular differentiation and development

    Author : Tove Berg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : C EBP transcription factors; lung; development; differentiation; glucocorticoid regulation;

    Abstract : During embryonic development the lung is lined with a primitive epithelium. As development proceeds, the epithelium matures and differentiates into several cell types that together with cells of mesenchymal origin constitute the adult lung. READ MORE