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Showing result 1 - 5 of 296 swedish dissertations matching the above criteria.

  2. 1. Dissecting the Microenvironment of Urothelial Bladder Cancer : Therapy, Modelling and Biomarkers

    Author : Iliana Kyriaki Kerzeli; Sara Mangsbo; Tania de Gruijl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immuno-oncology; Tumor immunology; MALT1 inhibition; Urothelial bladder cancer; Tumor microenvironment; Immunologi; Immunology; Oncology; Onkologi; Urologi; Urology;

    Abstract : The complexity of the tumor microenvironment (TME) impacts therapy responses and the survival of cancer patients. The scope of this thesis is to study the effects of immune modulation on tumor-infiltrating leukocytes, and to explore the TME of urothelial cancer to provide the research society with new knowledge and potential therapeutic targets. READ MORE

  4. 2. Cytokines as diagnostic biomarkers in canine pyometra and sepsis

    Author : Iulia Karlsson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Sepsis is a syndrome with high morbidity, mortality and astronomical health care costs and it is challenging to diagnose both in humans and animals due to the lack of suitable diagnostic biomarkers. Although several types of proteins have been suggested as diagnostic biomarkers of sepsis, none of them were shown to be reliable for routine use in the clinical practice. READ MORE

  5. 3. The PD-1 pathway and the complement system in systemic lupus erythematosus

    Author : Helga Kristjánsdóttir; Marta E Alarcón-Riquelme; Kristján Steinsson; Tom W J Huizinga; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; SLE; autoimmune diseases; PD-1; C4AQ0; low MBL; multicase family; Immunology; Immunologi; medicinsk genetik; Medical Genetics;

    Abstract : Autoimmune diseases occur in up to 3-5% of the general population and represent a diverse collection of diseases with regards to clinical manifestations. The unifying factor of autoimmune diseases is tissue and organ damage as a result of an immune response mounted against self-antigens. READ MORE

  6. 4. The Clinical and Pathological Spectrum of Idiopathic Inflammatory Myopathies : Implications for pathogenesis, classification and diagnosis

    Author : Olof Danielsson; Jan Ernerudh; Magnus Vrethem; Göran Solders; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Background: Idiopathic inflammatory myopathies (IIM) constitute a heterogeneous group of diseases with severe consequences for the life of affected patients. Dermatomyositis, polymyositis and inclusion body myositis (IBM) are the classical representatives of this group. READ MORE

  7. 5. Curing Multiple Sclerosis : How to do it and how to prove it

    Author : Joachim Burman; Jan Fagius; Angelica Loskog; Sara Mangsbo; Paulo Muraro; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biomarkers; cerebrospinal fluid; cytokines; hematopoietic stem cell transplantation; immunology; magnetic resonance imaging; multiple sclerosis; neuroimmunology; neurology; Neurology; Neurologi;

    Abstract : Hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for multiple sclerosis (MS) with now more than 600 documented cases in the medical literature. Long-term remission can be achieved with this therapy, but when is it justified to claim that a patient is cured from MS? In attempt to answer this question, the outcome of the Swedish patients is described, mechanisms behind the therapeutic effect are discussed and new tools for demonstration of absence of disease have been developed. READ MORE