Search for dissertations about: "Clinical Linear"

Showing result 1 - 5 of 384 swedish dissertations containing the words Clinical Linear.

2. 1. The future of clinical trials for Alzheimer's disease. A blood-based biomarker perspective

   Author : Nicholas Cullen; Klinisk minnesforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Biomarkers; Cognition; Amyloid; Tau; Neurodegeneration;

   Abstract : Objectives: The primary objective was to investigate the utility of blood-basedbiomarkers of amyloid, tau, and neurodegeneration for (i) screening, (ii)enrichment, and (iii) tracking response to treatment in clinical trials of Alzheimer’sdisease.Methods: Longitudinal, participant-level data used in these studies was drawn fromthe Swedish BioFINDER study and the ADNI study. READ MORE

4. 2. Evaluation of regression methods for log-normal data - linear models for environmental exposure and biomarker outcomes

   Author : Sara Gustavsson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; log-normal distribution; linear models; absolute effects;

   Abstract : The identification and quantification of associations between variables is often of interest in occupational and environmental research, and regression analysis is commonly used to assess these associations. While exposures and biological data often have a positive skewness and can be approximated with the log-normal distribution, much of the inference in regression analysis is based on the normal distribution. READ MORE

5. 3. Clinical studies of thiopurine metabolism in inflammatory bowel disease

   Author : Ulf Hindorf; Lund Medicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastroenterologi; Gastro-enterology; thiopurine methyltransferase; 6-mercaptopurine; azathioprine; Inflammatory bowel disease; thiopurines; adverse events; methylated metabolites; thioguanine nucleotides;

   Abstract : Inflammatory bowel disease (IBD, i.e. primarily Crohn's disease and ulcerative colitis) is characterised by a chronic or relapsing inflammation of the digestive tract. READ MORE

6. 4. Benefits of Non-Linear Mixed Effect Modeling and Optimal Design : Pre-Clinical and Clinical Study Applications

   Author : Charles Ernest II; Andrew Hooker; Mats Karlsson; Bart Ploeger; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; optimal design; nonlinear mixed effects models; population models; Pharmaceutical Science; Farmaceutisk vetenskap;

   Abstract : Despite the growing promise of pharmaceutical research, inferior experimentation or interpretation of data can inhibit breakthrough molecules from finding their way out of research institutions and reaching patients. This thesis provides evidence that better characterization of pre-clinical and clinical data can be accomplished using non-linear mixed effect modeling (NLMEM) and more effective experiments can be conducted using optimal design (OD). READ MORE

7. 5. Type 1 diabetes in children with non-Swedish background : epidemiology and clinical outcome

   Author : Ulf Söderström; Jan Åman; Ulf Samuelsson; Anders Hjern; Jannet Svensson; Örebro universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; HbA1c; children; adolescents; ethnicity; epidemiology; immigration; adoption; socio-demographic; registers; Medicine; Medicin;

   Abstract : Sweden holds third place of diabetes incidence in young people after Finland and Sardinia. One fifth of the population is nowadays of foreign descent. We have a substantial number of immigrants from countries where the risk for T1D is considerably lower. READ MORE