Search for dissertations about: "Clinical and pharmacogenetics"

Showing result 1 - 5 of 24 swedish dissertations containing the words Clinical and pharmacogenetics.

  2. 1. Clinical Pharmacogenetics of Olanzapine : with Focus on FMO Gene Polymorphisms

    Author : Mao Mao Söderberg; Marja-Liisa Dahl; Maria Gabriella Scordo; Inger Johansson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; olanzapine; pharmacogenetics; drug metabolism; schizophrenia; therapeutic drug monitoring; FMO1; FMO3; CYP1A2; UGT1A4; Clinical Pharmacology; Klinisk farmakologi;

    Abstract : Pharmacogenetics is the study of variability in drug response attributed to genetic variation. Olanzapine (OLA) is a widely used antipsychotic drug for schizophrenia treatment. The pharmacokinetics of OLA display large inter-individual variation leading to multiple-fold differences in drug exposure between patients at a given dose. READ MORE

  4. 2. Therapeutic Drug Monitoring in Psychiatry : Some aspects of utility in clinical practice and research

    Author : Maria Dolores Chermá Yeste; Finn Bengtsson; Johan Ahlner; Ylva Böttiger; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TDM; psychoactive drug; pharmacokinetics; pharmacogenetics; naturalistic; elderly; child; Clinical pharmacology; Klinisk farmakologi;

    Abstract : Background and objectives: Several new psychoactive drugs for the treatment of psychiatric disorders have been introduced onto the market since the late 1980s. Basic aspects of pharmacodynamics and pharmacokinetics (PK) are investigated before approval for general prescription. READ MORE

  5. 3. Pharmacometric Models for Individualisation of Warfarin in Adults and Children

    Author : Anna-Karin Hamberg; Mia Wadelius; E Niclas Jonsson; Lena E Friberg; Jeffrey S Barrett; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; warfarin; pharmacokinetics; pharmacodynamics; pharmacometrics; pharmacogenetics; dose individualisation; children; Klinisk farmakologi; Clinical Pharmacology;

    Abstract : Warfarin is one of the most widely used anticoagulants. Therapy is complicated by warfarin’s narrow therapeutic range and pronounced variability in individual dose requirements. Although warfarin therapy is uncommon in children, it is crucial for children with certain congenital or acquired heart diseases. READ MORE

  6. 4. Cardiovascular Risk Genes in Prevention and Treatment Response

    Author : Viktor Hamrefors; Kardiovaskulär forskning - hypertoni; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; blood pressure treatment; hypertension; statins; dyslipidemia; cardiovascular prevention; cardiovascular genetics; stroke; coronary artery disease; chromosome 9p21; pharmacogenetics; pharmacogenomics;

    Abstract : GENERAL AIM: To investigate how common single-nucleotide-polymorphisms (SNPs) that associate with cardiovascular disease (CVD) could be used in prevention and treatment of CVD. SUBJECTS: Subjects from the population-based Malmö-Diet-and-Cancer-(MDC)-Study (n=30447) and hypertensives from the Nordic-Diltiazem-(NORDIL)-Study (n=10881). READ MORE

  7. 5. Pharmacogenetic Studies of Paclitaxel in Ovarian Cancer : focus on interindividual differences in pharmacodynamics and pharmacokinetics

    Author : Henrik Green; Curt Peterson; Peter Söderkvist; Per Rosenberg; Håkan Melhus; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacogenetics; paclitaxel; LC MS; Taxol; ovarian cancer; pharmacokinetics; CYP2C8; CYP3A4; ABCB1; äggstockscancer; paklitaxel; Clinical pharmacology; Klinisk farmakologi;

    Abstract : Ovarian cancer is one of the most common female cancer diseases in the world today and in Sweden more than 800 new cases are diagnosed every year. The standard treatment consists of chemotherapy with paclitaxel in combination with carboplatin after initial cytoreductive surgery. READ MORE