Search for dissertations about: "Clopidogrel"

Showing result 1 - 5 of 31 swedish dissertations containing the word Clopidogrel.

  2. 1. Platelet Inhibition in Coronary Artery Disease – Mechanisms and Clinical Importance : Studies with Focus on P2Y12 Inhibition

    Author : Christoph Varenhorst; Stefan James; Agneta Siegbahn; Lars Wallentin; Steen Dalby Kristensen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; coronary artery disease; myocardial infarction; acute coronary syndromes; stent thrombosis; P2Y12 inhibitors; thienopyridines; clopidogrel poor response; clopidogrel; prasugrel; Cardiology; Kardiologi; Kardiologi; Cardiology;

    Abstract : Despite the currently recommended dual antiplatelet treatment (DAT) with aspirin and P2Y12 inhibition in patients with coronary artery disease (CAD) there is a risk of adverse clinical outcome. Pharmacodynamic (PD) poor response to clopidogrel occurs in ~ 30% of clopidogrel-treated patients and is associated with an increased risk of recurrent thrombotic events. READ MORE

  4. 2. Improving outcomes in patients with coronary heart disease using national registers and platelet function testing

    Author : Sasha Koul; Kardiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; STEMI; NSTEMI; ACS; Ticagrelor; clopidogrel; prasugrel; treatment delays; bivalirudin; heparin; platelet function testing;

    Abstract : Introduction: Ischemic heart disease is the leading cause of death worldwide. The aims of this thesis were to evaluate different contemporary approaches in coronary care with regard to mortality and myocardial infarction. READ MORE

  5. 3. Hydrolases as Catalysts for Green Chemistry and Industrial Applications - Esterase, Lipase and Phytase

    Author : Yasser Gaber; Bioteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; HPLC-EAT; sustainable environment; mutation; metallo-enzyme; phytate; b-propeller; biodegraqdable; metrics; green chemistry; Novozym 435; CalB; solvent-free; kinetic resolution; Biocatalysis; rational design; PLE; esterase; clopidogrel; enantioselectivity;

    Abstract : The use of enzymes in industrial applications has been recognised for providing clean processes with minimal impact on the environment. This thesis presents studies on engineering of enzymes and enzyme-based processes in the light of green chemistry and environmental sustainability, and focuses on three hydrolases: esterase, lipase and phytase. READ MORE

  6. 4. Studies of platelet function, and effects of aspirin and clopidogrel treatment

    Author : Christina Perneby; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Antiplatelet therapy with aspirin and clopidogrel is a cornerstone in cardiovascular prevention and lowers cardiovascular mortality and morbidity in patient with coronary artery disease (CAD). Mental stress and physical exertion can trigger acute coronary events and prothrombotic responses to stress may contribute to such triggering. READ MORE

  7. 5. Aprotinin for reduction of bleeding and transfusions in patients on clopidogrel undergoing urgent coronary surgery

    Author : Gabriella Lindvall; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Acute coronary syndrome; aprotinin; clopidogrel; platelets; surgery; tranexamic acid; transfusions;

    Abstract : Background: An increased proportion of patients with acute coronary syndrome undergo coronary surgery while treated with clopidogrel, an irreversible platelet ADP-receptor inhibitor. Clopidogrel in combination with aspirin is known to augment bleeding, transfusion requirements, and reoperation rates after coronary surgery. READ MORE