Search for dissertations about: "Co-activator"

Showing result 1 - 5 of 33 swedish dissertations containing the word Co-activator.

2. 1. Molecular mechanisms of the transcriptional co-activator mastermind-like 1

   Author : Magnus L Hansson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Gene regulation is a complex process that requires several types of proteins, including chromatin-modifying enzymes, transcription factors, co-activators and co-repressors. We have investigated the molecular mechanisms underlying the action of the co-activator protein MAML1, which was first identified as a transcriptional co-activator for Notch receptors. READ MORE

4. 2. Structure and function of the yeast mediator tail domain

   Author : Jenny Béve; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Transcription; RNA polymerase II; Co-activator; Mediator; Tail- module;

   Abstract : Mediator is a co-regulator complex that transduces regulatory information from activators and repressors to the RNA polymerase 11 transcription machinery. Mediator was originally discovered in Saccharomyces cerevisiae and since then Mediator-like complexes have been isolated in a number of organisms including mammals. S. READ MORE

5. 3. Pathogenesis of type 2 diabetes with emphasis on the mechanism of insulin resistance

   Author : Jeanette Kuhl; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Acetyl CoA carboxylase; AMP-activated protein kinase; Glucose intolerance; Insulin secretion; Insulin sensitivity; Malonyl CoA; Malonyl CoA decarboxylase; Peroxisomal proliferator activated receptor ã co-activator 1 á; Type 2 diabetes heredity;

   Abstract : Type 2 diabetes is characterized by chronic hyperglycemia and develops slowly through stages of early impairments of glucose metabolism. The disease is often associated with obesity, physical inactivity, decreased insulin sensitivity and impaired insulin responsiveness. READ MORE

6. 4. Evolution and Binding Mechanisms of Intrinsically Disordered Proteins

   Author : Elin Karlsson; Per Jemth; Kaare Teilum; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intrinsically disordered proteins; Protein evolution; Binding kinetics; Binding mechanisms; Biophysical characterisation; Medicinsk biokemi; Medical Biochemistry;

   Abstract : Intrinsically disordered proteins (IDPs) make up a considerable fraction of the proteome in eukaryotic organisms. These proteins often act as hubs in interaction networks, harbouring multiple interaction with other proteins, and thus evolution has to walk a tightrope to accommodate new interactions while maintaining the previously established interactions. READ MORE

7. 5. From membrane to nucleus : new roles and functions of SUMOylated IGF-1R and EGFR

   Author : Sylvia Packham; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Cell surface receptor tyrosine kinases (RTKs) role in cell signaling have been studied for decades and their role in cancer progression are undisputable. The insulin-like growth factor 1 receptor, IGF-1R, has been demonstrated to play a critical part in tumorigenesis; downregulation of the IGF-1R in tumor xenografts results in complete tumor regression. READ MORE