Search for dissertations about: "Co-activator"

Showing result 1 - 5 of 30 swedish dissertations containing the word Co-activator.

  1. 1. Molecular Mechanisms of the Transcriptional co-activator Mastermind-Like 1

    Author : Magnus L. Hansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Gene regulation is a complex process that requires several types of proteins, including chromatin-modifying enzymes, transcription factors, co-activators and co-repressors. We have investigated the molecular mechanisms underlying the action of the co-activator protein MAML1, which was first identified as a transcriptional co-activator for Notch receptors. READ MORE

  2. 2. Structure and function of the yeast mediator tail domain

    Author : Jenny Béve; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Transcription; RNA polymerase II; Co-activator; Mediator; Tail- module;

    Abstract : Mediator is a co-regulator complex that transduces regulatory information from activators and repressors to the RNA polymerase 11 transcription machinery. Mediator was originally discovered in Saccharomyces cerevisiae and since then Mediator-like complexes have been isolated in a number of organisms including mammals. S. READ MORE

  3. 3. Pathogenesis of type 2 diabetes with emphasis on the mechanism of insulin resistance

    Author : Jeanette Kuhl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Acetyl CoA carboxylase; AMP-activated protein kinase; Glucose intolerance; Insulin secretion; Insulin sensitivity; Malonyl CoA; Malonyl CoA decarboxylase; Peroxisomal proliferator activated receptor ã co-activator 1 á; Type 2 diabetes heredity;

    Abstract : Type 2 diabetes is characterized by chronic hyperglycemia and develops slowly through stages of early impairments of glucose metabolism. The disease is often associated with obesity, physical inactivity, decreased insulin sensitivity and impaired insulin responsiveness. READ MORE

  4. 4. From membrane to nucleus: New roles and functions of SUMOylated IGF-1R and EGFR

    Author : Sylvia Packham; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Cell surface receptor tyrosine kinases (RTKs) role in cell signaling have been studied for decades and their role in cancer progression are undisputable. The insulin-like growth factor 1 receptor, IGF-1R, has been demonstrated to play a critical part in tumorigenesis; downregulation of the IGF-1R in tumor xenografts results in complete tumor regression. READ MORE

  5. 5. Transcriptional Regulation of the Platelet-Derived Growth Factor B-receptor by p53 Family Members

    Author : Daniel Wetterskog; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : ;

    Abstract : Aims: The platelet-derived growth factor ?-receptor (PDGFRB) is critically involved in embryonic development and has a role in many diseases. In cells, signaling through PDGFRB affects growth, migration and death. READ MORE