Search for dissertations about: "Co-activator"

Showing result 16 - 20 of 33 swedish dissertations containing the word Co-activator.

  2. 16. Transcription regulation across levels of chromatin organization

    Author : Roshan Vaid; Mattias Mannervik; Goncalo Castelo-Branco; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transcription; chromatin; epigenetics; Drosophila; embryo development; molekylär biovetenskap; Molecular Bioscience;

    Abstract : With advancements in high-throughput sequencing and high-resolution microscopy techniques, the significance of genome organization in transcription regulation is rapidly unveiling. Nonetheless, we are yet far from completely understanding this key relationship. READ MORE

  4. 17. Studies of transcription factor domains and their interactions with other transcription factors

    Author : Monica E. Ferreira; Anthony Wright; Kurt Berndt; Iain McEwan; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The studies in this thesis deal with different questions concerning interactions of functional domains of factors involved in transcriptional regulation. The first study of this thesis is focused on the target factor binding mechanism of transcriptional activators. READ MORE

  5. 18. Transcriptional and epigenetic regulation of gene expression by arsenic in cancer and normal cells

    Author : Angeliki Pournara; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Inorganic arsenic is a toxic metalloid that occurs naturally on the earth’s crust. Millions of people worldwide are exposed to inorganic arsenic via drinking water, and more recently also via contaminated food, in particular rice. READ MORE

  6. 19. Modulation of the HPA axis alters the sensitivity of the cochlea to acoustic trauma

    Author : Yeasmin Tahera; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HPA axis; corticosterone; glucocorticoid receptor; NFêB; spiral ganglion neurons; cochlea; acoustic trauma; paraventricular nucleus;

    Abstract : The hypothalamic pituitary adrenal axis (HPA axis) regulates nearly all neuroendocrine responses of the body. An active HPA axis is crucial to maintaining homeostasis. An altered reactivity of the HPA axis can affect several physiological systems including the auditory system. READ MORE

  7. 20. The role of genetic variation and DNA methylation in human glucose metabolism and type 2 diabetes

    Author : Tina Rönn; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gene expression; oxidative phosphorylation; GWAS; SNP; DNA methylation; epigenetics; type 2 diabetes;

    Abstract : The incidence of diabetes is increasing worldwide, with the most prevalent form being type 2 diabetes. Two fundamental processes contribute to the development of type 2 diabetes: insulin resistance in target organs and insufficient insulin secretion from the pancreatic beta-cells. READ MORE