Search for dissertations about: "Codeine"

Showing result 6 - 10 of 12 swedish dissertations containing the word Codeine.

  2. 6. Pharmacokinetic aspects of the blood-brain barrier transport and equilibration of opioids studied with microdialysis in rats and mice

    Author : Rujia Xie; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Abstract : The blood-brain barrier (BBB) transport and equilibration of opioids with different physico-chemical properties and similar structures - codeine, morphine, morphine3-glucuronide (M3G) and morphine-6-glucuronide (M6G) - were investigated in rats and mice using microdialysis. The influences of active efflux pumps, P-glycoprotein (Pgp) and multidrug resistance protein (MRP1), on the BBB transport of morphine and M3G were studied. READ MORE

  4. 7. Studies of drug disposition in hemodialysis patients : impact of genetics, inflammation and vitamin D

    Author : Hadi Molanaei; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chronic kidney disease (CKD) patients are at a high risk for drug adverse effects due to accumulation of drugs, which normally are excreted via the kidneys. It is believed that drugs that are metabolized by the liver are safe to prescribe in normal doses to end-stage renal disease (ESRD) patients. READ MORE

  5. 8. Analytical and Toxicological Aspects of Drug Incorporation into Human Hair

    Author : Robert Kronstrand; Pascal Kintz; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The overall purpose of this thesis was to develop analytical methods for the determination of drugs and melanin content of human hair for practical use in forensic and clinical toxicology. The thesis consists of five papers, two of which are controlled single dose studies where codeine or selegiline were administered to healthy volunteers. READ MORE

  6. 9. Growth hormone regulation of hepatic drug-metabolising enzymes in humans and rats

    Author : Eva Rasmussen; Uppsala universitet; []
    Keywords : Medical sciences; growth hormone; IGF-I; somatostatin; cytochrome P450; regulation; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Abstract : There are pronounced sex-differences in the gene expression of several liver enzymes in the rat. The sex-differentiated secretion of growth hormone (GH) regulates these differences. We wanted to further investigate the mechanisms of this regulation in rats and to study the GH regulation of drug metabolism in man. READ MORE

  7. 10. Characteristics of cytochrome P450-catalysed drug metabolism with focus on a black Tanzanian population

    Author : Agneta Wennerholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Drug metabolism; cytochrome P450; polymorphism; pharmacogenetics; genotyping; phenotyping; CYP2D6; CYP3A; debrisoquine; amodiaquine; alprazolam;

    Abstract : The cytochrome P450 (CYP) enzymes display interindividual and interethnic variability that may alter the disposition of substances metabolised by these enzymes. Both genetic and environmental factors such as concomitant drug use and concurrent diseases influence the activities of these enzymes. READ MORE