Search for dissertations about: "Codon reading"

Showing result 1 - 5 of 25 swedish dissertations containing the words Codon reading.

  2. 1. From Structure to Function with Binding Free Energy Calculations for Codon Reading, Riboswitches and Lectins

    Author : Johan Sund; Åqvist Johan; Javier Luque; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; binding free energy; ribosome; codon reading; release factor; mitochondrial translation; purine riboswitch; lectin; molecular dynamics; free energy perturbation; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Abstract : Molecular association is part of many important processes in living cells. Computational methods for calculating binding free energies allows for a quantitative examination of biomolecular structures and hypotheses drawn from biochemical experiments. READ MORE

  4. 2. Computational Studies of Protein Synthesis on the Ribosome and Ligand Binding to Riboswitches

    Author : Christoffer Lind; Johan Åqvist; Alexander MacKerell Jr; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Binding free energy; Ribosome; Codon reading; Translation initiation; Translation termination; Mitochondrial translation; Release factor; Purine riboswitch; Molecular Dynamics; Free Energy Perturbation; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : The ribosome is a macromolecular machine that produces proteins in all kingdoms of life. The proteins, in turn, control the biochemical processes within the cell. It is thus of extreme importance that the machine that makes the proteins works with high precision. READ MORE

  5. 3. Wobble modifications and other features in transfer RNA important for decoding and reading frame maintenance

    Author : Joakim Näsvall; Glenn Björk; Michael O'Connor; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Transfer RNA; Modified nucleosides; Decoding; Reading frame maintenance; Molecular biology; Molekylärbiologi;

    Abstract : Transfer RNA (tRNA) is the adaptor molecule responsible for bringing the correct amino acid to the ribosome during protein synthesis. tRNA contains a number of modified nucleosides, which are derivatives of the four normal nucleosides. READ MORE

  6. 4. Evolutionary Mechanisms Shaping Bacterial Translation Termination

    Author : Shreya Pundir; Suparna Sanyal; Martin Ott; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Protein; Release Factor; Translation; Termination; Stop codon; Evolution; Mutation; Kinetics; Cryo-EM; Molekylär biovetenskap; Molecular Life Sciences;

    Abstract : Translation termination in bacteria involves precise reading of stop codons (UAA, UAG, UGA) and coordinated peptidyl-tRNA hydrolysis by the class-I release factors (RFs) on the ribosome (70S). This thesis investigates the evolutionary and post-translational modification mechanisms of these RFs and the concurrent effect on bacterial translation termination. READ MORE

  7. 5. Posttranscriptional Regulation of Human Papillomavirus Type 16 Late mRNAs

    Author : Brian Collier; Carl Baker; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; HPV 16; Negative Element; Translation; mRNA stability; Codon Usage; RNA binding proteins; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Abstract : The lifecycle of the human papillomavirus (HPV) is strictly linked to the programmed differentiation of the host cell it infects. Production of late proteins, which are used for the production of the major and minor capsid proteins, is only seen upon terminal differentiation of the epithelium. READ MORE