Search for dissertations about: "Cohesin complex"

Showing result 6 - 10 of 10 swedish dissertations containing the words Cohesin complex.

  1. 6. Molecular architecture of meiotic chromosomes

    University dissertation from Stockholm : Karolinska Institutet, Department of Cell and Molecular Biology

    Author : Ivana Novak; Karolinska Institutet.; Karolinska Institutet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Meiosis; Chromosome architecture; Synaptonemal complex; Cohesin complex;

    Abstract : Faithful chromosome segregation at each cell division is essential as the formation of cells with an abnormal number of chromosomes (aneuploid cells) can result in infertility, developmental defects or cancer. Aneuploidy occurs in approximately 20% of all conceptions, causing infertility and embryo death. READ MORE

  2. 7. Studies of cohesin functions in the yeast and human DNA damage response

    University dissertation from Stockholm : Karolinska Institutet, Dept of Cell and Molecular Biology

    Author : Elin Enervald; Karolinska Institutet.; Karolinska Institutet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Maintaining genome stability is critical to cell survival and normal cell growth and most human cancers display some form of genome instability. Genome instability is caused by multiple reasons and the ability to properly recognize, signal and subsequently repair DNA damages is crucial. READ MORE

  3. 8. The role of the cohesin loader in genome stability : a journey from yeast to human

    University dissertation from Stockholm : Karolinska Institutet, Dept of Cell and Molecular Biology

    Author : Fosco Giordano; Karolinska Institutet.; Karolinska Institutet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Structural Maintenance of Chromosome (SMC) complexes, as their name suggests, have a central role in maintaining the higher structure of genomes, from bacteria to human, and in doing so protecting their integrity. Cohesin, one of three SMC complexes, is required to hold sister chromatids together until anaphase, and for homologous recombination-based DNA repair. READ MORE

  4. 9. Molecular analysis of protein complexes involved in pairing of mammalian chromosomes during meiosis

    University dissertation from Stockholm : Karolinska Institutet, Department of Cell and Molecular Biology

    Author : Jeanette Pelttari Danielsson; Karolinska Institutet.; Karolinska Institutet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : How is the accuracy of chromosomal pairing and segregation processes in dividing meiotic cells assured? This is an important question as premature or erratic segregation of chromosomes can give rise to aneuploidy, which is the leading genetic cause of pregnancy loss in humans. Meiosis is a cell division process that produces genetically unique haploid gametes from diploid cells. READ MORE

  5. 10. Proteins influencing the integrity of meiotic chromosome dynamics

    University dissertation from Stockholm : Karolinska Institutet, Center for Genomics Research

    Author : Mary-Rose Hoja; Karolinska Institutet.; Karolinska Institutet.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Aneuploidy (trisomy or monosomy) is the leading genetic cause of human pregnancy loss and results from aberrant meiotic chromosome segregation. Accurate segregation of meiotic chromosomes depends on extensive pairing (called synapsis) and recombination between them. READ MORE