Search for dissertations about: "Cohesin complex"
Showing result 6 - 10 of 14 swedish dissertations containing the words Cohesin complex.
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6. Mechanisms behind Smc5/6 transcriptional regulation and cohesin-mediated chromosome organisation
Abstract : The eukaryotic family of Structural Maintenance of Chromosomes (SMC) complexes are multi-subunit, ring-like protein complexes and include condensin, cohesin and the Smc5/6 complex (Smc5/6). Considered as an entity, this family is essential for most chromosome-based processes, and protects against diverse human syndromes and diseases. READ MORE
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7. Molecular architecture of meiotic chromosomes
Abstract : Faithful chromosome segregation at each cell division is essential as the formation of cells with an abnormal number of chromosomes (aneuploid cells) can result in infertility, developmental defects or cancer. Aneuploidy occurs in approximately 20% of all conceptions, causing infertility and embryo death. READ MORE
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8. Studies of cohesin functions in the yeast and human DNA damage response
Abstract : Maintaining genome stability is critical to cell survival and normal cell growth and most human cancers display some form of genome instability. Genome instability is caused by multiple reasons and the ability to properly recognize, signal and subsequently repair DNA damages is crucial. READ MORE
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9. The role of the cohesin loader in genome stability : a journey from yeast to human
Abstract : Structural Maintenance of Chromosome (SMC) complexes, as their name suggests, have a central role in maintaining the higher structure of genomes, from bacteria to human, and in doing so protecting their integrity. Cohesin, one of three SMC complexes, is required to hold sister chromatids together until anaphase, and for homologous recombination-based DNA repair. READ MORE
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10. Molecular analysis of protein complexes involved in pairing of mammalian chromosomes during meiosis
Abstract : How is the accuracy of chromosomal pairing and segregation processes in dividing meiotic cells assured? This is an important question as premature or erratic segregation of chromosomes can give rise to aneuploidy, which is the leading genetic cause of pregnancy loss in humans. Meiosis is a cell division process that produces genetically unique haploid gametes from diploid cells. READ MORE