Search for dissertations about: "Collision-activated dissociation CAD"

Found 2 swedish dissertations containing the words Collision-activated dissociation CAD.

2. 1. Characterization of Polypeptides by Tandem Mass Spectrometry Using Complementary Fragmentation Techniques

   Author : Michael Lund Nielsen; Roman A. Zubarev; Per Andrén; Ole Nörregaard Jensen; Uppsala universitet; []
   Keywords : Analytical chemistry; Mass Spectrometry; Electron capture dissociation ECD ; Collision-activated dissociation CAD ; Proteomics; Post-translational modifications; De Novo sequencing; Bioinformatics; Analytisk kemi;

   Abstract : In the growing field of proteomics identification of proteins by tandem mass spectrometry (MS/MS) is performed by matching experimental mass spectra against calculated spectra of all possible peptides in a protein database. One problem with this approach is the false-positive identifications. READ MORE

4. 2. New Proteomics Methods and Fundamental Aspects of Peptide Fragmentation

   Author : Mikhail Savitski; Roman Zubarev; Per Andren; David Fenyö; Uppsala universitet; []
   Keywords : Bioinformatics; Proteomics; Peptide fragmentation; Bioinformatik;

   Abstract : The combination of collision-activated dissociation, (CAD) and electron capture dissociation, (ECD) yielded a 125% increase in protein identification. The S-score was developed for measuring the information content in MS/MS spectra. This measure made it possible to single out good quality spectra that were not identified by a search engine. READ MORE