Search for dissertations about: "Comparison of gene therapy"
Showing result 1 - 5 of 36 swedish dissertations containing the words Comparison of gene therapy.
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1. CD40L Gene Therapy for Solid Tumors
Abstract : Adenoviral CD40L gene therapy (AdCD40L) is a strong inducer of anti-tumor immune responses via its activation of dendritic cells (DCs). Activated DCs can in turn activate T cells, which are key players in an efficient anti-tumor response.This thesis includes three papers that focus on different aspects of AdCD40L gene therapy. READ MORE
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2. Dendritic cells in immune and gene therapy against cancer
Abstract : Dendritic cells (DC) are extensively used for vaccine therapy due to their superior T cell stimulatory capacity. However, the modest therapeutic effects reported by most clinical trials using DC, together with the rapid developing field of DC biology suggests important considerations for improvement of the clinical outcome. READ MORE
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3. Radiolabelled Oligonucleotides for Evaluation of in vivo Hybridisation Utilising PET Methodology
Abstract : Antisense oligonucleotides (ODN) may interfere in gene expression on the basis of hybridising to its complementary messenger RNA (mRNA) sequence in the cell thereby preventing the synthesis of the peptide. Therefore, these ODNs may be potential drugs to treat human diseases by “knocking down” the expression of responsible genes or correcting the maturation process of mRNA in the field called antisense therapy. READ MORE
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4. Characterization and applications in muscle of a Minicircle vector for Nonviral gene therapy
Abstract : In gene therapy, the aim is to change the behaviour of a cell by introduction of genetic material, often DNA encoding a protein or a therapeutic RNA. The purpose can be to replace a malfunctioning copy of a gene, as in clinical trials for treatment of X-linked severe combined immunodeficiency, or introduce a new gene into the body to help fight a disease, as has been done in clinical trials for e. READ MORE
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5. Elucidation of the molecular mechanisms of action of anti-cancer compounds reveals possible combination strategies for anti-cancer therapy
Abstract : Cancer develops due to accumulation of mutations or epigenetic changes within normal cells, usually over a considerable period of time. When cancer patients are diagnosed at late stage, the tumor cells are often more heterogenous and aggressive, which results in tumor resistance to anti-cancer therapies and therefore can be lethal. READ MORE
