Search for dissertations about: "Complement activation"

Showing result 21 - 25 of 213 swedish dissertations containing the words Complement activation.

  2. 21. Innate immunity in diabetes mellitus. Complement components C4BP and C3 promote survival of β cells under metabolic challenges

    Author : Klaudia Kulak; Malmö Proteinkemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Complement System; Inflammasome; Islet Amyloid Polypeptide; Complement C3; C4b-binding protein C4BP ; Interleukin 1β; Autophagy-Related Protein 16 like 1; Diabetes mellitus; type 2;

    Abstract : The Complement system is a main effector mechanism of the innate immune system, acting to enhance clearance of pathogens, but also aids removal of biological debris from the body, including immunocomplexes, apoptotic/necrotic cells and protein aggregates. Complement regulators serve to prevent excessive inflammation and their interaction with the same materials targeted by the complement system results in ‘silent’ cleaning of wastes. READ MORE

  4. 22. Titanium Oxide and Bone Anchorage: Role of the Complement System, and Delivery of Osteoporosis Drugs from Mesoporous TiO2

    Author : Necati Harmankaya; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; titania; complement; photocatalysis; ovariectomy; alendronate; raloxifene;

    Abstract : The clinical success of bone implants of titanium (Ti) is largely ascribed to the biological performance and the physicochemical properties of the outermost titanium(IV)dioxide (TiO2) layer. Several advancements have been done on TiO2 in order to optimize its healing and anchorage to bone, and there is a need for further understanding and control of the molecular reactions preceding long-term osseointegration. READ MORE

  5. 23. Feedback Enhancement of Immune Responses by IgE, IgM, and IgG3 Antibodies

    Author : Zhoujie Ding; Birgitta Heyman; Eva Severinson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IgE; IgM; IgG3; antibody responses; T-cell responses; antigen transportation; antigen presentation; complement; complement receptors 1 and 2; Immunologi; Immunology;

    Abstract : Antibodies can enhance or suppress the immune responses against their specific antigens. This phenomenon is known as antibody-mediated feedback regulation. We have studied the mechanisms underlying IgE-, IgM-, and IgG3-mediated enhancement of immune responses in mouse models using intravenous immunization. READ MORE

  6. 24. Development and evaluation of immunoassays for complement diagnostics

    Author : Kerstin Sandholm; Kristina Nilsson Ekdahl; Ingvar Ryden; Linnéuniversitetet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immune assays; complement diagnostics; xMAP-technology; C1q; preanalytical factors; method validation; Immunologi; Immunology;

    Abstract : Laboratory analyses of human body fluids play an important role in clinical diagnosis. This thesis comprises projects in which various immune assays have been developed and evaluated as complement diagnostics in both plasma and cerebrospinal fluid (CSF). READ MORE

  7. 25. Complement in Autoimmunity - the importance of clearing waste

    Author : Jonatan Leffler; Malmö Proteinkemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; annexins; apoptosis; Complement system; neutrophil extracellular traps; systemic lupus erythematosus; C1q; factor H; histones;

    Abstract : Systemic lupus erythematosus (SLE) is an autoimmune disease where improperly cleared apoptotic cells and neutrophil extracellular traps (NETs) induce an autoimmune response. Complement is crucial to prevent SLE by tailoring immune responses and opsonizing dead cells but may also induce inflammation and tissue damage once the disease is initiated. READ MORE