Search for dissertations about: "Complement inhibition"

Showing result 1 - 5 of 57 swedish dissertations containing the words Complement inhibition.

  2. 1. Complement in Disease - Extracellular Proteins as Complement Regulators

    Author : Kaisa Happonen; Malmö Proteinkemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; joint disease; Complement; proteoglycan; cancer;

    Abstract : Complement activation occurs during inflammatory joint diseases such as rheumatoid arthritis (RA) and is thought to contribute to the chronic inflammation observed within the joints. Previous studies have shown that certain cartilage components of the small leucine-rich repeat protein (SLRP)-family regulate complement activity, thereby possibly contributing to disease progression. READ MORE

  4. 2. The role of the thromboinflammatory response under hemolytic conditions : pathophysiological mechanisms and therapeutic inhibition

    Author : Alexandra Gerogianni; Per H. Nilsson; Camilla Mohlin; Tom Eirik Mollnes; Kristina Nilsson Ekdahl; Mihály Józsi; Linnéuniversitetet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hemolysis; heme; thromboinflammation; biomaterials; complement inhibition; LVAD; IONPs; Biomedical Sciences; Biomedicinsk vetenskap; Immunologi; Immunology;

    Abstract : In blood circulation, the complement and the coagulation cascades, together with platelets and endothelial cells form a complex network of crosstalk. When dysregulated, these interactions can lead to inflammation in combination with thrombosis (thromboinflammation) and the manifestation of pathophysiological complications. READ MORE

  5. 3. Synaptic elimination and the complement system in Alzhaimer's disease

    Author : Jonny Daborg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Synapse; Alzheimer s disease; Genetics; CSF; Complement; RAGE;

    Abstract : The mechanisms behind Alzheimer’s disease (AD) are largely unknown. The disease is to a large extent hereditary, and the best pathophysiological correlate to the severity of the symptoms is loss of synapses. READ MORE

  6. 4. Effects of Complement Opsonization of HIV on Dendritic Cells : and Implications for the Immune Response

    Author : Rada Ellegård; Marie Larsson; Jorma Hinkula; Johan D Söderholm; William Paxton; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; HIV; dendritic cells; complement; innate immune response; TLR signaling; T cell activation; NK cells; inflammation; antiviral response; immune evasion;

    Abstract : Dendritic cells are key players during HIV pathogenesis, and shape both the immediate immune response at the site of infection as well as directing the adaptive immune response against the virus. HIV has developed a plethora of immune evasion mechanisms that hijack dendritic cell functions, suppressing their ability to mount an accurate immune response and exploiting them for efficient viral transfer to target T cells. READ MORE

  7. 5. Complement-mediated kidney diseases: Genotype, phenotype and inhibition studies

    Author : S.S. Aradottir; Lund Pediatrik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; The complement system; factor B; factor D; danicopan; Atypical hemolytic uremic syndrome; C3 glomerulopathy; Membranoproliferative glomerulonephritis; genes; monozygotic twins;

    Abstract : Complement-mediated kidney diseases are ultrarare conditions characterized by excess complement activation related in most cases to complement gene variants or circulating autoantibodies. These conditions are chronic and can lead to kidney failure. READ MORE