Search for dissertations about: "Complementarity Determining Regions"

Showing result 1 - 5 of 8 swedish dissertations containing the words Complementarity Determining Regions.

2. 1. Control of Epstein-Barr virus infection by cytotoxic T lymphocytes

   Author : Pedro-Otavio de Campos-Lima; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Epstein-Barr virus; Cytotoxic T lymphocytes; T cell receptor; CTLescape mutants;

   Abstract : Cytotoxic T lymphocytes (CTL) play a critical role in response to Epstein-Barr virus (EBV), a widespread human herpes virus that persists in healthy carriers as a latent infection of B cells and is implicated in the pathogenesis of lymphoid and epithelial cell malignancies. Six virus encoded nuclear antigens, EBNA1-6, and three membrane proteins, LMP1, -2A and -2B, are regularly detected in EBV transformed lymphoblastoid cell lines (LCLs). READ MORE

4. 2. The immunoglobulin genes in an Actinopterygian fish, the Siberian sturgeon (Acipenser baeri)

   Author : Mats Lundqvist; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Immunoglobulin genes; gene organization; transmembrane TM ; comparative immunology; Siberian sturgeon Acipenser baerii ; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molecular Immunology; molekylär immunologi;

   Abstract : Characterization of the immunoglobulin (Ig) light (L) and heavy (H) chain genes from the Siberiansturgeon, Acipenser baeri, revealed an Ig structure simhar to the IgM elass of mammals. The serumforms of the sturgeon Ig are tetrameric and dimeric. READ MORE

5. 3. Antibody Evolution and Repertoire Development

   Author : Johan Lantto; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; virus neutralization; trinucleotide repeat; insertion; immunoglobulin variable genes; human cytomegalovirus; glycoprotein B; deletion; antibody; antibody repertoire;

   Abstract : Antibodies are key players of the immune system in higher vertebrates, which provide a defense against potentially lethal threats from the environment. Besides their importance in the immune defense, antibodies have a great potential as reagents in biological chemistry and diagnostics, and as therapeutic agents against both infectious diseases and cancer. READ MORE

6. 4. Engineering Antibody Specificity Using Combinatorial Antibody Libraries

   Author : Jenny Boström; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; antibody Antigen Interactions; Dual Specific Antibodies; Herceptin; Human Epidermal Growth Factor Receptor 2; Thermodynamic Analysis; therapeutic Antibody Engineering; Synthetic Phagedisplayed Antibody Libraries; Vascular Endothelial Growth Factor; Bacterial Display; trastuzumab;

   Abstract : The research presented in this thesis investigates antibody specificity, antibody-antigen and protein-protein interactions using combinatorial antibody libraries, phage-display and bacterial display technology. One goal was to develop a method to generate antibodies that bind two protein antigens with high affinity using a single-antigen binding site, and to investigate the molecular and thermodynamic requirements for antibody multispecificity. READ MORE

7. 5. Antibody-Fragments: Protein Engineering, Process Development, and their Application as Affinity Ligands

   Author : Laila Sakhnini; Tillämpad biokemi; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Monoclonal Antibodies; Aggregation; Biophysical Characterisation; Process Development; Affinity Adsorbents; Monoclonal Antibodies; Aggregation; Biophysical Characterisation; Process Development; Affinity Adsorbents;

   Abstract : Monoclonal antibody (mAb) fragments have become the formats of choice for both biopharmaceuticals and ligands in analytical and preparative applications. Their smaller size enables additional advantages over full-length mAbs, such as improved tissue penetration, faster blood clearance for diagnostic applications, improved capacity, and enablement of multivalent formatting. READ MORE