Search for dissertations about: "Compound Exocytosis"

Showing result 1 - 5 of 6 swedish dissertations containing the words Compound Exocytosis.

  2. 1. Nature of Large Vesicle Exocytosis in Pancreatic β-cells: Release of ATP and GABA

    Author : Jovita Karanauskaite; Islet cell physiology; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ATP; LDCV; Insulin; exocytosis; Compound Exocytosis; Calcium;

    Abstract : Several high resolution electrophysiological techniques such as measurements of cell membrane capacitance and amperometry are used to detect exocytotic events. A novel method was developed in this study based on the expression of P2X2 receptor channel in secreting cells. READ MORE

  4. 2. Calcium dynamics and vesicle-release proteins in a prion-infected neuronal cell line

    Author : Malin Sandberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Prion; Scrapie; Voltage-gated N-type calcium channels; SNARE proteins; Exocytosis; Long-term depolarization;

    Abstract : The prion particle, PrPSc, is an infectious, misfolded form of the cellular prion protein, PrPC that is expressed at high levels in the central nervous system. Prions cause neurodegenerative diseases with clinical signs including dementia, ataxia and myoclonus. These diseases cause characteristic electroencephalographic changes. READ MORE

  5. 3. Stimulation of insulin secretion independently from changes in cytosolic free Ca²+-concentration : studies with imidazolines and inositol polyphosphates

    Author : Alexander Efanov; Karolinska Institutet; Karolinska Institutet; []
    Keywords : insulin secretion; pancreatic ß-cell; imidazolines; inositol polyphosphates;

    Abstract : Insulin secretion from the islets of Langerhans is regulated by changes in glucose concentration. Glucose stimulates secretion by two mechanisms. First, it increases cytosolic free Ca2+ concentration ([Ca2+]i) by inhibition of ATP-dependent K+-channels (KATP) and induction of membrane depolarization. READ MORE

  6. 4. Anti-diabetic and anti-inflammatory effects of medicinal plants in a type 2 diabetic animal model

    Author : Ezarul Faradianna Lokman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Type 2 diabetes;

    Abstract : Medicinal plants have been suggested since ancient times to be a good source of drugs for treating diabetes. The aims of this thesis were to identify the anti-diabetic effects and to understand further the mechanisms involved for two traditional plants, borapetol B (C1) isolated from Tinospora crispa, and Gynostemma pentaphyllum (GP), in diabetic rats. READ MORE

  7. 5. Assessment of anti-diabetic effect of Vietnamese herbal drugs

    Author : Nguyen Khanh Hoa; Karolinska Institutet; Karolinska Institutet; []
    Keywords : G-protein; type 2 diabetes; phanoside; antidiabetic plant; hypoglycemic agent; insulin secretion; pancreatic islets; Gynostemma pentaphyllum; Anemarrhena asphodeloides; Angiopteris evecta;

    Abstract : The prevalence of type 2 diabetes mellitus is increasing in Vietnam as well as in other developing countries (China, Indian subcontinent, and Africa). Searching for hypoglycemic agents with origin from domestic herbals was considered as a useful way to find novel therapy of the disease. After treatment i.p. READ MORE