Search for dissertations about: "Computational statistics"

Showing result 16 - 20 of 160 swedish dissertations containing the words Computational statistics.

  2. 16. Mixed Effects Modeling of Deterministic and Stochastic Dynamical Systems - Methods and Applications in Drug Development

    Author : Jacob Leander; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; pharmacometrics; pharmacokinetics; mixed effects; drug development; pharmacodynamics; parameter estimation; time-to-event; mathematical modeling; dynamical systems;

    Abstract : Mathematical models based on ordinary differential equations (ODEs) are commonly used for describing the evolution of a system over time. In drug development, pharmacokinetic (PK) and pharmacodynamic (PD) models are used to characterize the exposure and effect of drugs. READ MORE

  4. 17. Towards Precision Medicine: Exploiting Genetic Variation in Tumours by Inferring Multitype Gene Regulatory Networks

    Author : Tobias Abenius; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; precision medicine; survival; cancer; gene regulatory networks; high-dimensional data; LASSO; Reproducible research; Generalized Pairwise Fused LASSO; Split Bregman;

    Abstract : Precision medicine aims to customize treatment to a patient given measured genetic or other molecular data for diagnostics. In cancer, optimal medical treatment, depends on how far the disease has progressed, type and subtype of cancer and, the individual tumor’s circumstances. READ MORE

  5. 18. Kinetic Models in Life Science — Contributions to Methods and Applications

    Author : Joachim Almquist; Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik (FCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NLME modeling; kinetic models; FOCE; Mig1; cell-to-cell variability; pharmacokinetics; parameter estimation; ticagrelor; atrial fibrillation; Kv1.5;

    Abstract : Kinetic models in life science combine mathematics and biology to answer questions from areas such as cell biology, physiology, biotechnology, and drug development. The idea of kinetic models is to represent a biological system by a number of biochemical reactions together with mathematical expressions for the reaction kinetics, i.e. READ MORE

  6. 19. Nonlinear Mixed Effects Modeling of Combination Therapies in Oncology

    Author : Marcus Baaz; Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik (FCC); []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacol- ogy; Radiation Therapy; Oncology; Mathematical Modeling; Combination Therapy; Nonlinear Mixed Effects;

    Abstract : It has been shown that simultaneous administration of two or more anticancer agents can have a beneficial effect on cancer patients. This type of treatment is called combination therapy and is nowadays commonly used in the fight against cancer. READ MORE

  7. 20. Modeling of bacterial DNA patterns important in horizontal gene transfer using stochastic grammars

    Author : Mariana Buongermino Pereira; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Stochastic context-free grammars; hidden Markov model; conditional random fields; integrons; attC sites; secondary structure.; secondary structure.;

    Abstract : DNA contains genes which carry the blueprints for all processes necessary to maintain life. In addition to genes, DNA also contains a wide range of functional patterns, which governs many of these processes. These functional patterns have typically a high variability, both within and between species, which makes them hard to detect. READ MORE