Search for dissertations about: "Connexins"

Found 4 swedish dissertations containing the word Connexins.

  2. 1. Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models

    Author : Thomas Asklund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glioma; gap junction; Cx43; bystander effect; HSV-tk; HDAC inhibitor; tyrosine kinase inhibitor;

    Abstract : The group of patients suffering from the malignant brain tumour glioblastoma multiforme (GBM) have a median survival of only about one year. Thus, new treatment strategies are urgently needed. Gap junctions are intercellular channels, permitting intercellular transfer of water soluble substances. READ MORE

  4. 2. Neural stem cell engraftment : functional interactions, brain repair and gap junctions

    Author : Johan Jäderstad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neural stem cell (NSC) engraftment therapies show increasing promise as potential cures for several of the diseases of the central nervous system. Traditionally, functional improvements after NSC engraftment have been attributed to replacement of lost neurons and astrocytes, remyelination and support of adjacent cells at risk. READ MORE

  5. 3. Connexin43 in astroglial gap junctions. Regulation by age, neurotransmitters, GH and IGF-I

    Author : N David Åberg; Göteborgs universitet; []
    Keywords : Connexin43; rat; development; hypophysectomy; primary culture; ; mRNA; gap junction; somatotropin; IGF-I; serotonin; glutamate; ; brain region heterogeneity; calcium wave; astrocyte; astroglial cell; ; gap junctional coupling.;

    Abstract : Connexins form gap junctions that are aqueous pores allowing low-molecular (.... READ MORE

  6. 4. New insights into the control of small artery function in human pregnancy and estrogen receptor beta knockout mice

    Author : Leanid Luksha; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Available data clearly indicates functional and morphological differences between small and large arteries, and observations from studies on large arteries may not be applicable to understand the physiology of small arteries (~200-300mum) that actively participate in the regulation of peripheral vascular resistance, blood pressure and flow to target organs. These events confer cardiovascular adaptation to normal pregnancy (NP), however they are disturbed in preeclampsia (PE) and in estrogen receptor beta knockout (ERbetaKO) mice at a certain age. READ MORE