Search for dissertations about: "Cooperativity"

Showing result 16 - 20 of 59 swedish dissertations containing the word Cooperativity.

  2. 16. Cooperativity between MYC and other oncogenic factors : implications for tumorigenesis and targeting of MYC

    Author : Siti Mariam Zakaria; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Normal cell homeostasis in a tissue requires a delicate balance between cell growth, maintenance and death, tightly controlled by an intricate interplay between proto-oncogenes and tumor suppressor genes. When the balance is tipped due to genetic or epigenetic lesions in such genes, diseases such as cancer may arise. READ MORE

  4. 17. Characterization and optimization of the in vitro motility assay for fundamental studies of myosin II

    Author : Malin Persson; Alf Månsson; Carlo Reggiani; Linnéuniversitetet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Myosin II; skeletal muscle; actomyosin; in vitro motility assay; protein adsorption; cargo transportation; CapZ; cross-bridge cycle; inter-head cooperativity; processivity; Biomedical Sciences; Biomedicinsk vetenskap;

    Abstract : Myosin II is the molecular motor responsible for muscle contraction. It transforms the chemical energy in ATP into mechanical work while interacting with actin filaments in so called cross-bridge cycles. Myosin II or its proteolytic fragments e.g. READ MORE

  5. 18. Unravelling Mechanistic Insights of Eukaryotic Transcriptional Control

    Author : Johanna Hörberg; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Transcriptional control; Gene expression regulation; DNA supercoiling; DNA methylation; DNA-protein recognition; Basic-Leucine-Zipper transcription factors; Basic-Helix-Loop-Helix transcription factors; Sequence specific DNA plasticity; Transcription factor cooperativity; Cancer; Molecular modelling; Molecular dynamics;

    Abstract : DNA transcription involves the association of multiple proteins with DNA to convert the genetic information into messenger-RNA transcripts, which later will be translated into proteins. Con-trolled regulation of transcription is imperative for preserving the healthy and homeostatic state of cells. READ MORE

  6. 19. Molecular aspects of glutathione synthetase deficiency

    Author : Runa Vidar Njålsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glutathione synthetase; kinetics; cooperativity; substrate affinity; splice mutations; phenotype; genotype;

    Abstract : The tripeptide glutathione (GSH) is involved in several crucial pathways in the cell, for instance regulation of enzyme activity, DNA synthesis, and free radical scavenging. Synthesis of GSH takes place via two steps in the gamma-glutamyl cycle. READ MORE

  7. 20. Exploring Selectivity and Hysteresis : Kinetic Studies on a Potato Epoxide Hydrolase

    Author : Diana Lindberg; Mikael Widersten; Gunnar Johansson; Richard N. Armstrong; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Epoxide hydrolase; regioselectivity; selectivity; hysteresis; conformational changes; cooperativity; deep eutectic solvents; methylstyrene oxide; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Abstract : The kinetic mechanism of an α/β hydrolase fold epoxide hydrolase from potato, StEH1, has been studied with the aims of explaining the underlying causes for enantio- and regioselectivity, both being important for product purity. Further effort has been laid upon understanding the causes of a hysteretic behavior discovered in the measurements leading to Paper I. READ MORE