Search for dissertations about: "Copy number variation"
Showing result 11 - 15 of 58 swedish dissertations containing the words Copy number variation.
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11. Genomic and transcripto variation in blood stage Plasmodium falciparum
Abstract : Malaria research has entered a postgenomic era since October 2002, when the complete genomic sequence of Plasmodium falciparum strain 3D7 was published. A massive amount of information generated by the P. falciparum genome project has facilitated the development of many novel platforms for profiling different levels of biological aspects. READ MORE
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12. Array-based Genomic and Epigenomic Studies in Healthy Individuals and Endocrine Tumours
Abstract : The human genome is a dynamic structure, recently recognized to present with significant large-scale structural variation. DNA-copy number changes represent one common type of such variation and is found both between individuals and within the somatic cells of the same individual, especially in disease states like cancer. READ MORE
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13. Pancreatic Cancer. Experimental and Clinical Studies
Abstract : Background: Pancreatic cancer is one of the most lethal of known cancers and the only treatment with possibility of cure is surgery. The costs associated with treatment of pancreatic cancer are reputably high, both in terms of morbidity and financially. READ MORE
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14. Genetic Determinants of Obesity in Relation to Diet, Weight Gain and Mortality
Abstract : Obesity is one of the major health concerns that has reached epidemic proportions globally. It is generally believed to be a result of interactions between genetic and environmental factors. READ MORE
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15. Somatic Genetic Variation in Children: from Mosaicism to Cancer
Abstract : This thesis concerns various aspects of somatic mosaicism and genetic intratumor heterogeneity in childhood cancer.In paper I, I show that aneuploidy in itself does not lead to the level of chromosomal instability that is typically seen in malignant cells. This finding strongly argues against the so called autocatalytic theory of carcinogenesis. READ MORE