Search for dissertations about: "Copy number variations"
Showing result 1 - 5 of 39 swedish dissertations containing the words Copy number variations.
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1. Modelling Allelic and DNA Copy Number Variations using Continuous-index Hidden Markov Models
Abstract : In human cells there are usually two copies of each chromosome, but in cancer cells abnormalities could exist. The differences consist of segments of chromosomes with an altered number of copies. There can be deletions as well as amplifications and the lengths of the segments can also vary. READ MORE
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2. Extracting Genomic Variations using Selector Technology
Abstract : This thesis describes the development and use of a new class of molecular tools called Selector probes, and its potential for investigations of genetic variation. The Selector technology provides multiplex amplification of targeted DNA sequences with a high specificity, and an enrichment factor in the same order of magnitude as PCR. READ MORE
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3. Genetic studies of children with mental retardation
Abstract : Mental retardation (MR) is characterised by significant limitations in intellectual function and adaptive behaviour. It is estimated that MR affects up to 3% of the population in Europe. Patients with MR are an aetiologically heterogeneous group. Approximately 25-35% of the patients have a genetic diagnosis. READ MORE
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4. Pancreatic Cancer. Experimental and Clinical Studies
Abstract : Background: Pancreatic cancer is one of the most lethal of known cancers and the only treatment with possibility of cure is surgery. The costs associated with treatment of pancreatic cancer are reputably high, both in terms of morbidity and financially. READ MORE
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5. Analysis of chromosomal rearrangements and gene copy number changes in breast cancer cells
Abstract : Genome changes in terms of numerical chromosomal aberrations and structural rearrangements, including deletions, amplifications and translocations, gradually accumulate in the genome during tumor development. These genomic changes are likely to play an important role in the process of tumor progression. READ MORE