Search for dissertations about: "Corticostriatal"

Showing result 11 - 13 of 13 swedish dissertations containing the word Corticostriatal.

  2. 11. Progressive models of Parkinson's disease : behavioural and neurochemical analyses

    Author : Alexandra Alvarsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Parkinson’s disease (PD) is a common neurodegenerative disorder diagnosed based on the presence of motor symptoms, including resting tremor, postural impairment, bradykinesia and rigidity. The pathological hallmarks are degeneration of midbrain dopaminergic neurons and the accumulation of inclusions containing the misfolded protein α-synuclein (termed “Lewy bodies”) throughout the nervous system. READ MORE

  4. 12. Modeling Biochemical Network Involved in Striatal Dopamine Signaling

    Author : Anu G. Nair; Jeanette Hellgren Kotaleski; Omar Gutierrez Arenas; Upinder Singh Bhalla; Jakob Kisbye Dreyer; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dopamine signaling; Striatum; Reward learning; Acetylcholine; Mass-action modeling; FRET biosensor; Adenosine; Eligibility trace; Computer Science; Datalogi;

    Abstract : In this thesis, I studied the molecular integration of reward-learning related neuromodulatory inputs by striatal medium-sized projection neurons (MSNs) using mass-action kinetic modeling.It is known that, in reward learning, an unexpected reward results in transient elevation in dopamine (peak) whereas omission of an expected reward leads to transient dopamine decrease (dip). READ MORE

  5. 13. Organization of brain circuits that control motivated behaviors

    Author : Ourania Tzortzi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Eudemonia (Greek: εὐδαιμονία) is an anthropocentric term describing the absolute well-being in the Aristotelian ethics, along with the terms “arête” (virtue) and “phronesis” (wisdom from an ethical and practical point of view). Arête and virtue will guide ones decisions to promote future eudemonia and ultimately survival. READ MORE