Search for dissertations about: "CpG DNA"
Showing result 1 - 5 of 85 swedish dissertations containing the words CpG DNA.
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1. Arthritogenic property of bacterial DNA containing CpG motifs
Abstract : .... READ MORE
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2. Modulation of inflammation by immunostimulatory DNA
Abstract : The aim of this thesis was to elucidate the roles of different types of DNA in inflammatory responses. We compared the immune responses to nuclease-protected phosphorothioate oligodeoxynucleotides (S-ODNs) and phosphodiester oligodeoxynucleotides (O-ODNs) that either contained or lacked CpG motifs. READ MORE
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3. DNA vaccines and bacterial DNA in immunity
Abstract : This thesis describes DNA-based vaccination and the importance of bacterial DNA in different immunological perspectives. Intranasal (i.n.) DNA vaccination utilizing a plasmid encoding the chlamydial heat shock protein 60 (p-hsp-60) generated lower bacterial burden and reduced pathology in the lungs of mice after subsequent infection with C. READ MORE
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4. Inflammatogenic properties of endogenous DNA
Abstract : Bacterial DNA and CpG-containing oligodeoxynucleotides (ODNs) induce host inflammatory responses as a result of their content of unmethylated ¡§CpG motifs¡¨. Since the CpG motifs in the mitochondrial (mt) genome are in this respect similar to bacterial DNA, in that they are non-methylated, we investigated whether mtDNA also displays inflammatogenic potential. READ MORE
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5. The CpG island methylator phenotype in colorectal cancer : studies on risk and prognosis
Abstract : Background Colorectal cancer (CRC) is the second most common malignancy in developed countries. The mortality is high, with nearly half of patients dying from the disease. The primary treatment of CRC is surgery, and decisions about additional treatment with chemotherapy are based mainly on tumor stage. READ MORE