Search for dissertations about: "CpG islands"
Showing result 1 - 5 of 18 swedish dissertations containing the words CpG islands.
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1. Genome-wide epigenetic profiling of B cell leukemia and lymphoma
Abstract : Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, phenotypes, and cellular fates. In this work, we investigated the aberrant epigenome in chronic lymphocytic leukemia (CLL) which is one of the most frequent lymphoid malignancies in the west including the Nordic countries. READ MORE
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2. Meiotic Recombination in Human and Dog : Targets, Consequences and Implications for Genome Evolution
Abstract : Understanding the mechanism of recombination has important implications for genome evolution and genomic variability. The work presented in this thesis studies the properties of recombination by investigating the effects it has on genome evolution in humans and dogs. READ MORE
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3. Molecular characterization of the hepatitis C virus core protein
Abstract : Hepatitis C virus (HCV) is an RNA virus that causes chronic infection, which can lead to hepatocellular carcinomas in humans. Besides liver diseases, the chronic HCV infection causes a broad spectrum of extrahepatic complications such as lymphoproliferative, metabolic and autoimmune disorders. READ MORE
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4. Novel extrahepatic P450 enzymes with emphasis on the tumor specific CYP2W1
Abstract : Cytochrome P450 is a superfamily of enzymes involved in the metabolism of endogenous and exogenous compounds. The P450 enzymes are expressed at high levels in the liver, but are also found in extrahepatic tissues and in transformed tissues. READ MORE
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5. Development of new approaches for tumor suppressor genes identification
Abstract : Development of tumor is a complex process involving multiple steps. New technologies for cloning and identifying genes playing critical role in cancer development are necessary. That is why we have focused our research on development of these approaches. READ MORE