Search for dissertations about: "CreERT2"

Showing result 1 - 5 of 7 swedish dissertations containing the word CreERT2.

  2. 1. Cdc42, orchestrator of vascular morphogenesis in the retina

    Author : Alberto Álvarez-Aznar; Konstantin Gängel; Christer Betsholtz; Taija Mäkinen; Ondine Cleaver; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cdc42; endothelial cell; pericyte; mural cell; angiogenesis; CreERT2; Medicinsk vetenskap; Medical Science;

    Abstract : Cdc42 is a small GTPase that controls many cellular functions related to cytoskeletal dynamics, such as migration, polarity, and proliferation. Despite what we know of Cdc42 in other cell types, not much research has been done on the vasculature. READ MORE

  4. 2. Taking Pressure of Anaplastic Thyroid Carcinoma : Molecular Studies of Apoptosis and Interstitial Hypertension

    Author : Pernilla Roswall; Nils-Erik Heldin; Kristofer Rubin; Sven Påhlman; Uppsala universitet; []
    Keywords : Medicine; Anaplastic thyroid carcinoma; Apoptosis; Cre recombinase; 2-Methoxyestradiol; Transforming growth factor-β; Transgenic mouse; Tumor-associated macrophages; Tumor interstitial fluid pressure; Medicin;

    Abstract : Molecular mechanisms in the development and progression of thyroid carcinomas are still not fully understood. In the present thesis the highly malignant anaplastic thyroid carcinoma (ATC) was used to study regulation of apoptosis and tumor interstitial fluid pressure (IFP). READ MORE

  5. 3. Determine the developmental dynamics of primordial follicles in the mouse ovary

    Author : Wenjing Zheng; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ovary; primordial follicles; germline stem cell; cell lineage tracing;

    Abstract : Ovarian follicles are the basic functional units of the mammalian ovary. Progressive activation of primordial follicles serves as the source of fertilizable ova. READ MORE

  6. 4. Lymphatic Vascular Morphogenesis : From Progenitors to Functional Vessels

    Author : Nina Daubel; Taija Mäkinen; Markus Affolter; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lymphatic vasculature; morphogenesis; lymphvasculogenesis; mesentery; lymphatic capillary;

    Abstract : The lymphatic vasculature is an important part of the circulatory system and crucial for normal functioning and maintenance of tissues. Yet, our understanding of the processes underlying lymphatic development and homeostasis are surprisingly limited. READ MORE

  7. 5. Molecular pathways mediating the development of female germ cells

    Author : Sanjiv Risal; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Ovary; primordial follicles; primordial germ cells; Oogonial stem cells;

    Abstract : In mice, primordial germ cells (PGCs) dramatically increase in their number from 200 cells at 9.5 dpc to 10 000 cells at 12.5 dpc with doubling time of 12.6 hours. READ MORE