Search for dissertations about: "Creutzfeldt-Jakob"

Showing result 1 - 5 of 10 swedish dissertations containing the word Creutzfeldt-Jakob.

  2. 1. Biochemical markers in dementia - Exploring Swedish registry data and the human proteome

    Author : Tobias Skillbäck; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomarkers; Dementia; Alzheimer s disease; Vascular dementia; Creutzfeldt Jakob disease; Lewy body dementia; Frontotemporal dementia; Parkinson s disease dementia;

    Abstract : Cerebrospinal fluid (CSF) biomarkers of neurodegenerative diseases have a wide scope of applications in diagnostics, prognosis assessment, disease staging, treatment evaluation and more. In this PhD project we aimed to expand the understanding of the properties of known CSF biomarkers of Alzheimer’s disease (AD) and other neurodegenerative diseases, including the most prevalent dementia disorders. READ MORE

  4. 2. Interactions of Prion Proteins and PrP-derived Peptides in Scrapie infection

    Author : Kajsa Löfgren Söderberg; Astrid Gräslund; Marcus Fändrich; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Spongiform encephalopathy; Creutzfeldt-Jakob disease; Amyloidosis; Neurodegeneration; Cell penetrating peptide; Protein Transduction Domain; Heparan sulfate; Proteoglycan; Glypican; Src family kinase; Fyn; Biochemistry; Biokemi; Biochemistry; biokemi;

    Abstract : Prion diseases are fatal and incurable spongiform encephalopathies that occur amongst mammals. The central pathological event is the misfolding of the cellular prion protein (PrPC) into an amyloid, neurotoxic isoform called scrapie (PrPSc). PrPSc is the main, or sole, constituent of infectious prions. READ MORE

  5. 3. Modeling Amyloid Disease in Drosophila melanogaster

    Author : Ina Berg; Per Hammarström; Stefan Thor; Damian Crowther; Linköpings universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : Amyloid diseases are caused by protein misfolding and aggregation. To date there are 27 known proteins causing amyloid disorders involving brain and peripheral protein deposition. The proteins involved in this mechanism do not share sequence homology, but the amyloid fibrils share biophysical properties and possibly a common pathogenic mechanism. READ MORE

  6. 4. Early events in disease associated protein misfolding

    Author : Sofie Nyström; Per Hammarström; Marcus Fändrich; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi;

    Abstract : The scope of this thesis is to unravel some of the mysteries concerning events takingplace early in the amyloid cascade. In vitro studies of early misfolded states ofamyloidogenic proteins are important since the use of recombinant proteins allow us to monitor slight changes in environmental conditions as well as in amino acid composition and thereby illuminate the problem at near atomic resolution. READ MORE

  7. 5. Synthesis and application of β-configured [18/19F]FDGs : Novel prosthetic CuAAC click chemistry fluoroglycosylation tools for amyloid PET imaging and cancer theranostics

    Author : Mathias Elgland; Peter Konradsson; Peter Nilsson; Per Hammarström; Olof Solin; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; FDG; clickable; PET; synthesis; in vivo imaging; theranostics;

    Abstract : Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. READ MORE