Search for dissertations about: "CsA"

Showing result 21 - 25 of 60 swedish dissertations containing the word CsA.

  2. 21. Blood-Brain Barrier Transport : Investigation of Active Efflux using Positron Emission Tomography and Modelling Studies

    Author : Stina Syvänen; Margareta Hammarlund-Udenaes; Mats Bergström; Gunnar Blomquist; Jashvant Unadkat; Uppsala universitet; []
    Keywords : Pharmaceutical biosciences; pharmacokinetics; P-glycoprotein; blood-brain barrier; modelling; PET; active efflux; species differences; [11C]verapamil; drug development; Farmaceutisk biovetenskap;

    Abstract : This thesis examines the transport of exogenous molecules across the blood-brain barrier (BBB), focusing on active efflux, using positron emission tomography (PET), computer simulation and modelling. P-glycoprotein (P-gp) inhibition was studied using [11C]verapamil and [11C]hydroxyurea was investigated as a new marker for active efflux transport. READ MORE

  4. 22. Circumventing drug resistance : Studies exploring the expediency of a total cell kill chemoresistance assay

    Author : Bertil Jonsson; Uppsala universitet; []
    Keywords : Medical sciences; drug resistance; drug resistance assay; clinical correlations; cancer; human; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Abstract : Cellular resistance to anti-cancer drugs is considered to be the major cause of treatment failure in clinical practice. The present studies have therefore focused on ways to circumvent resistance as evaluated by an in vitro chemoresistance assay. READ MORE

  5. 23. Orthogeriatric anaesthesia - studies on the bone cement implantation syndrome, risk prediction and intraoperative haemodynamics

    Author : Fredrik Olsen; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bone cement implantation syndrome; cemented hip hemiarthroplasty; bone cement; Nottingham hip fracture score; cardiac output monitoring; continuous spinal anaesthesia;

    Abstract : The bone cementation implantation syndrome (BCIS), as seen in orthopaedic patients, is characterised by intraoperative hypotension and hypoxia and loss of consciousness around the time of bone cementation. In a retrospective study, the incidence of and risk factors for the BCIS and its impact on mortality during cemented hemiarthroplasty for hip fracture were evaluated. READ MORE

  6. 24. Pursuing the fever trail : pathogenesis of blood-stage P. falciparum malaria and pregnancy

    Author : Niloofar Rasti; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Plasmodium falciparum; malaria; erythrocytes; pregnancy; Uganda; placental sequestration; cytoadhesion; PfEMP1; var2csa; antigenic variation; live-cell proteomic.;

    Abstract : The burden of the most virulent form of human malarias, Plasmodium falciparum, is concentrated among young children and pregnant women in sub-Saharan Africa. Excessive sequestration of parasite-infected red blood cells (pRBCs) in the capillary beds of different organs is the hallmark of P. READ MORE

  7. 25. Bit-Wise Decoders for Coded Modulation and Broadcast Coded Slotted ALOHA

    Author : Mikhail Ivanov; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; mutual information; vehicular communications; bit-interleaved coded modulation; error floor; slotted ALOHA; medium access control; All-to-all broadcast;

    Abstract : This thesis deals with two aspects of wireless communications. The first aspect is about efficient point-to-point data transmission. To achieve high spectral efficiency, coded modulation, which is a concatenation of higher order modulation with error correction coding, is used. READ MORE