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Showing result 1 - 5 of 8 swedish dissertations matching the above criteria.

  2. 1. Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models

    Author : Thomas Asklund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glioma; gap junction; Cx43; bystander effect; HSV-tk; HDAC inhibitor; tyrosine kinase inhibitor;

    Abstract : The group of patients suffering from the malignant brain tumour glioblastoma multiforme (GBM) have a median survival of only about one year. Thus, new treatment strategies are urgently needed. Gap junctions are intercellular channels, permitting intercellular transfer of water soluble substances. READ MORE

  4. 2. Connexin43 in astroglial gap junctions. Regulation by age, neurotransmitters, GH and IGF-I

    Author : N David Åberg; Göteborgs universitet; []
    Keywords : Connexin43; rat; development; hypophysectomy; primary culture; ; mRNA; gap junction; somatotropin; IGF-I; serotonin; glutamate; ; brain region heterogeneity; calcium wave; astrocyte; astroglial cell; ; gap junctional coupling.;

    Abstract : Connexins form gap junctions that are aqueous pores allowing low-molecular (.... READ MORE

  5. 3. Epigenetic mechanisms and regulatory aspects of human cancer and neural progenitor cells : implications for diagnosis and therapy

    Author : Monira Akhtar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Epigenetic is defined as heritable modification or properties of the functional genome that are not directly embedded in the DNA sequence. Epigenetic changes include DNA methylation, histone modifications and RNA-mediated gene silencing. READ MORE

  6. 4. Neural stem cell-mediated enhanced gene therapy of malignant gliomas using a novel plant thymidine kinase

    Author : Zahidul Khan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Malignant glioma; suicide gene therapy; bystander effect; gap junction; neural stem cell; 4-phenylbutyrate; epigenetics; cell differentiation;

    Abstract : Malignant gliomas are the most common brain tumors in adults. Approximately, 190,000 new patients are diagnosed with malignant gliomas worldwide every year. Unfortunately, the prognosis of malignant gliomas still remains very poor, despite advances in management. READ MORE

  7. 5. On CNS injury and olfactory ensheathing cell engraftment strategies

    Author : I-Hui Lee; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) is limited because of lack of nerve-growth stimulatory factors and presence of an insurmountable molecular environment for injured axons. This thesis aims to study neural regeneration following adult CNS injury, using rodent models of spinal cord injury, dorsal root avulsion, and Parkinson s disease. READ MORE