Search for dissertations about: "Cyclin-dependent kinases"

Showing result 1 - 5 of 21 swedish dissertations containing the words Cyclin-dependent kinases.

  2. 1. Interplay between the Myc oncoprotein, cyclin-dependent kinases and E3 ubiquitin ligases

    Author : Hamid Reza Sharifi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mammalian cells grow, divide, and die in a precise and orderly fashion. For cells to grow and maintain their integrity they need to communicate at both intracellular and extracellular level. READ MORE

  4. 2. Pharmacological and analytical studies of the cyclin dependent kinase inhibitors

    Author : Hatem H A Sallam; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cyclin-dependent kinases (Cdks) play a key role in the regulation of cell cycle progression and RNA transcription. Deregulation of Cdks has been associated with several malignancies, neurodegenerative disorders, viral and protozoal infections, glomerulonephritis and inflammatory diseases. READ MORE

  5. 3. Mechanisms of Medulloblastoma Dissemination and Novel Targeted Therapies

    Author : Sara Bolin; Fredrik Swartling; Martine F. Roussel; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; Recurrence; MYC; SOX9; FBW7; Treatment; BET bromodomains; Cyclin-dependent kinases; Oncology; Onkologi;

    Abstract : Medulloblastomas are the most frequent malignant childhood brain tumors, arising in the posterior fossa of children. The overall 5-year survival is 70%, although children often suffer severe long-term side effects from standard medical care. READ MORE

  6. 4. MYC-driven Medulloblastoma : New Targeted Therapies and Mechanisms of Recurrence

    Author : Anna Borgenvik; Fredrik J. Swartling; Lars-Gunnar Larsson; Sonja Hutter; Pratiti (Mimi) Bandopadhayay; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; Pediatric cancer; Recurrence; MYC; MYCN; SOX9; Treatment; Bet bromodomains; Cyclin-dependent kinases; Oncology; Onkologi; Medicinsk vetenskap; Medical Science;

    Abstract : Medulloblastoma is the most common malignant brain tumor of childhood. It arises in the posterior fossa but presents with distinct histological and molecular features. Hence, medulloblastoma is divided into four molecular subgroups, WNT, SHH, Group 3, and Group 4. READ MORE

  7. 5. In vitro modelling of tau phosphorylating kinases : emphasis of Cdk5

    Author : Anne Jämsä; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The main hallmarks of Alzheimer’s disease (AD) are extracellular deposits of betaamyloid (Aβ) and intracellular neurofibrillary tangles (NFT) composed of highly phosphorylated tau protein. Abnormal hyperphosphorylation of tau is the most deleterious step in NFT formation making the use of kinase inhibitors an attractive treatment possibility in AD. READ MORE