Search for dissertations about: "Cyclooxygenase inhibitors"

Showing result 1 - 5 of 38 swedish dissertations containing the words Cyclooxygenase inhibitors.

  2. 1. Cyclooxygenase-2 inhibitors and knee prosthesis surgery

    Author : Andreas Meunier; Lars Good; Per Aspenberg; Tore Dalén; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Non-steroidal anti-inflammatory agents; administration dosage; Arthroplasty; knee replacement; Surgical blood loss; Surgery; Cyclooxygenase inhibitors; Cyclooxygenase inhibitors; Fracture healing; Isoxazoles; Postoperative pain; Pyrazoles; Sulfonamides; Surgery; Kirurgi;

    Abstract : Adverse effects of cyclooxygenase (COX) inhibitors on bone healing have previously been demonstrated in diaphyseal fracture models in animals. In spite of that, they are widely used as postoperative analgesics in orthopaedic surgery. After joint replacement, a bone repair process starts at the interface between bone and cement. READ MORE

  4. 2. The Role of Cyclooxygenase-2 in Models of Epilepsy and Traumatic Brain Injury : Effects of Selective Cyclooxygenase-2 Inhibitors

    Author : Tina Kunz; Tadeusz Wieloch; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Controlled cortical contusion injury; fluid percussion injury; limbic seizures; nuclear factor-kappa B; prostaglandin metabolism; TUNEL staining; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Abstract : Cyclooxygenase-2 (COX-2) catalyses prostaglandin synthesis from arachidonic acid during inflammation. COX-2 is expressed in the normal brain and is induced in neurological disorders. There is evidence that COX-2 is involved in secondary events leading to cell death in the brain. READ MORE

  5. 3. Endocannabinoid metabolism : the impact of inflammatory factors and pharmacological inhibitors

    Author : Jessica Karlsson; Christopher Fowler; Stig Jacobsson; Jürg Gertsch; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endocannabinoid; anandamide; 2-AG; fatty acid amide hydrolase; cyclooxygenase-2; prostate cancer; catabolism; inflammation; inflammatory factors;

    Abstract : The endocannabinoid (eCB) system is an endogenous signaling system consisting of ligands (referred to as endocannabinoids, eCBs), receptors and metabolic enzymes. The eCB system is involved in homeostatic control of a variety of biological functions such as neuronal signaling, mood, appetite and pathological conditions such as pain, inflammation and tumour progression. READ MORE

  6. 4. Cyclooxygenase activity and tumor progression

    Author : Christian Cahlin; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclooxugenase; PGE2; inflammation; cytokine; nitric oxide; indomethacin; IL-6;

    Abstract : Invasive growth of malignant tumors is associated with local and systemic inflammation, which may promote progression and metastases. Inflammation is also responsible for appearing manifestations of advanced cancer as fatigue, anorexia and wasting with eicosanoids, proinflammatory cytokines and nitric oxide as mediators. READ MORE

  7. 5. Studies of prostaglandin E2 formationin human monocytes

    Author : Sofia Karlsson; Jonny Wijkander; Christina Gustafson-Svärd; Karlstads universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostaglandin E2; arachidonic acid; phospholipase A2; cyclooxygenase; prostaglandin E synthase; human monocytes; Medical cell biology; Medicinsk cellbiologi; Biomedical Sciences; Biomedicinsk vetenskap;

    Abstract : Prostaglandin (PG) E2 is an eicosanoid derived from the polyunsaturated twenty carbon fatty acid arachidonic acid (AA). PGE2 has physiological as well as pathophysiological functions and is known to be a key mediator of inflammatory responses. READ MORE