Search for dissertations about: "Cysteine protease inhibition"

Showing result 1 - 5 of 11 swedish dissertations containing the words Cysteine protease inhibition.

  1. 1. CYSTATIN C AND NEUROENDOCRINE DIFFERENTIATION IN THE MALE REPRODUCTIVE SYSTEM AND IN PROSTATE CANCER

    University dissertation from Department of Urology, Malmö University Hospital, 205 02 Malmö, Sweden

    Author : Thomas Jiborn; Lund University.; Lunds universitet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urology; androgen deprivation therapy; cysteine protease inhibitor; neuroendocrine differentiation; cysteine protease; male reproductive tract; prostate cancer; nefrologi; Urologi; nephrology;

    Abstract : Cystatins are endogenous protease inhibitors that regulate the proteolytic activities of family C1 (papain-like) cysteine proteases, such as human cathepsins B, H, K, L, and S. Cystatin C shows the fastest inhibition and the highest affinity of all cystatins towards lysosomal cysteine proteases in general and is widespread in human tissues and body fluids. READ MORE

  2. 2. Synthesis of Novel Inhibitors of IdeS, a Bacterial Cysteine Protease Including Studies of Stereoselective Reductive Aminations

    University dissertation from Department of Urology, Malmö University Hospital, 205 02 Malmö, Sweden

    Author : Kristina Berggren; Göteborgs universitet.; Gothenburg University.; [2011]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cysteine protease inhibition; IdeS; SpeB; Papain; Conformational restriction; Peptidomimetics;

    Abstract : Abstract The cysteine protease IdeS is an IgG degrading enzyme secreted by the bacterium Streptococcus pyogenes to evade the human immune system. In this thesis several inhibitors of IdeS have been synthesized and evaluated. Such inhibitors should be highly useful when elucidating the detailed mechanism of IdeS action. READ MORE

  3. 3. Cystatin C functions in vitro and in vivo. Studies on target enzyme inhibition by cystatin C variants and cystatin C deficient mice

    University dissertation from Department of Clinical Chemistry, Lund University

    Author : Katarina Håkansson; Lund University.; Lunds universitet.; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloidosis; E.coli expression; Cysteine proteases; protease inhibitors; Clinical chemistry; Klinisk kemi;

    Abstract : Cystatin C variants with Arg8, Leu9 and/or Val10 replaced by Gly residues were produced by site-directed mutagenesis and E. coli expression. READ MORE

  4. 4. Peptide-Based Inhibitors of Hepatitis C Virus NS3 Serine Protease: Kinetic Aspects and Inhibitor Design

    University dissertation from Uppsala : Institutionen för naturvetenskaplig biokemi

    Author : Anton Poliakov; Uppsala universitet.; [2004]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; serine protease; inhibitor; slow-binding; protein purification; Biokemi; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi;

    Abstract : Hepatitis C is a serious disease that affects about 200 million people worldwide. No anti-HCV vaccine or specific anti-viral drugs are available today. Non-structural protein 3 (NS3) of HCV is a bifunctional serine protease/helicase, and the protease has become a prime target in the search for anti-HCV drugs. READ MORE

  5. 5. Cellular Uptake of Cystatin C. Subcellular localisation and intracellular effects of a secreted cysteine protease inhibitor

    University dissertation from Division of Clinical Chemistry and Pharmacology, Faculty of Medicine, Lund University

    Author : Hanna Wallin; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cathepsin; cell line; co-localisation; cystatin C; internalisation; legumain;

    Abstract : Cystatin C is a cysteine protease inhibitor, aimed for secretion, as it is produced with a signal peptide. Its target enzymes are thought to be the lysosomal cysteine cathepsins and legumain. READ MORE