Search for dissertations about: "Cytidine deamination"
Found 3 swedish dissertations containing the words Cytidine deamination.
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1. Calculations of Reaction Mechanisms and Entropic Effects in Enzyme Catalysis
Abstract : Ground state destabilization is a hypothesis to explain enzyme catalysis. The most popular interpretation of it is the entropic effect, which states that enzymes accelerate biochemical reactions by bringing the reactants to a favorable position and orientation and the entropy cost of this is compensated by enthalpy of binding. READ MORE
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2. The Germinal Centre reaction - Genetic and proteomic analysis of factors important for survival and growth of B lymphocytes
Abstract : During an immune response the B lymphocytes main function is to produce antibodies in the specific defence against the pathogen. When naïve B lymphocytes become activated by binding of an antigen, the cells differentiate to become antibody producing plasma cells. READ MORE
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3. Role of DNA repair in class switch recombination and somatic hypermutation
Abstract : Class switch recombination (CSR) and somatic hypermutation (SHM), occurring in the germinal center, are two important processes for B cell development. Both are initiated by activation-induced cytidine deaminase (AID), through deamination of the C residues in the variable and switch regions of the immunoglobulin locus, resulting in either in single stranded or double stranded DNA breaks. READ MORE