Search for dissertations about: "Cytogenetic Analysis"

Showing result 11 - 15 of 59 swedish dissertations containing the words Cytogenetic Analysis.

2. 11. Investigation of cytogenetic markers in neonatal blood spots and of aberrant protein expression in bone marrow from children with leukemia

   Author : Kristin Mattsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The general aim of this thesis was to contribute to a better understanding of the development and progression of leukemia in children. Biological markers identified in children with leukemia can contribute to the understanding of leukemic development. READ MORE

4. 12. Genomic instability and tumor progression : a cytochemical, molecular biological and cytogenetic study of human tissue from uterine cervix, colon, breast and ovary

   Author : Harald Blegen; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Cervical; colorectal; breast; ovarian neoplasia; proliferation; DNA ploidy; cyclins; P53; CGH;

   Abstract : Disruption of cell cycle checkpoint control is believed to be common in human carcinomas. To elucidate how cell cycle defects and genomic instability cooperate we investigated the pathogenesis of carcinomas by using four different models of tumor progression in human tissue samples i.e. from the uterine cervix, colon, breast and ovary. READ MORE

5. 13. Functional studies of the multiple endocrine neoplasia type 1 gene

   Author : Lovisa Bylund; Karolinska Institutet; Karolinska Institutet; []
   Keywords : MEN1; menin; tumor suppressor gene; cancer; RNAi; promoter; expression; cytogenetic; microarray;

   Abstract : The multiple endocrine neoplasia type 1 (MEN1, OMIM 131 100) syndrome is an autosomal dominant trait with a near 100% penetrance and with an estimated prevalence of 2-20/100 000. The syndrome is characterized by neoplasia affecting the parathyroid glands (90-97%), enteropancreatic endocrine tissues (30-80%) and the anterior pituitary gland (15-50%) but tumors arc also found in other, both endocrine and non endocrine tissues. READ MORE

6. 14. Structural chromosomal aberrations and neuropsychiatric disorders

   Author : Tonnie Johannesson; Göteborgs universitet; []
   Keywords : Autism spectrum disorders; chromosomes; FISH; balanced; translocations;

   Abstract : Infantile autism (IA) is a severe neurodevelopment disorder with a complex genetic predisposition. The underlying causes of autism are still not understood. READ MORE

7. 15. Prognostic factors in squamous cell carcinoma of the head and neck, with emphasis on 11q13 rearrangements and cyclin D1 overexpression

   Author : Jan Åkervall; Lund näs- och halssjukdomar Öron-; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; audiologi; Otorinolaryngologi; auditive system and speech; audiology; head and neck; squamous cell carcinoma; genetics; prognosis; CCND1; chromosomes; cyclin D1; chemotherapy; Otorhinolaryngology; gene expression; hörsel- och talorganen;

   Abstract : At present, clinical outcome or response to therapy can not be fully predicted in individual cases of squamous cell carcinoma of the head and neck (SCCHN). The overall aim of the present studies was to investigate potential prognostic factors, more closely related to the malignant progression of a tumor than the established markers, such as the TNM-classification system. READ MORE