Search for dissertations about: "Cytogenetic Analysis"

Showing result 21 - 25 of 59 swedish dissertations containing the words Cytogenetic Analysis.

  2. 21. Characterisation of chromosomal aberrations in childhood leukaemia

    Author : Ann Nordgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Chromosome aberrations; SKY; interphase-FISH; Childhood ALL;

    Abstract : Acute lymphoblastic leukaemia (ALL) is the most common malignancy in childhood, accounting for approximately 25% of all paediatric malignancies. Based on clinical risk criteria and modem laboratory investigations including immunophenotyping, cytogenetics, and molecular genetics, patients can be divided into prognostic groups and assigned to risk- adjusted treatment protocols. READ MORE

  4. 22. Trisomies in Hematologic Malignancies

    Author : Kajsa Paulsson; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical genetics; Klinisk genetik; cytogenetik; Genetik; cytogenetics; Genetics; leukemia; chromosome aberration; trisomy;

    Abstract : Acquired clonal chromosome aberrations, closely associated with leukemogenesis, are found in many hematologic malignancies. Although the balanced rearrangements, such as translocations and inversions, are the ones most commonly thought of in the context of leukemias, gains of chromosomes ? e.g.. READ MORE

  5. 23. Molecular Cytogenetics in Sporadic Breast Cancer

    Author : Karin Rennstam; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; oncology; Cytology; Cytologi; cancer; gene expression; gene amplification; tumor development; cDNA microarray; fluorescence in situ hybridization FISH ; breast cancer; comparative genomic hybridization CGH ; cancerology; ERBB2;

    Abstract : In recent time breast cancer has become the most common form of female cancer in the western world. It has been estimated that the lifetime risk of women falling ill from the disease is 10%. The number of patients diagnosed each year has been increasing steadily since the 1970s. READ MORE

  6. 24. Genetic studies of acute lymphoblastic leukemia

    Author : Ekaterina Kuchinskaya; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, comprising approximately 25% of all childhood cancers. A huge improvement in outcome of children with ALL during the last 20 years has resulted in remission rates exceeding 95% and a 5 year event-free-survival approaching 80%. READ MORE

  7. 25. Molecular genetics of lymphoid malignancies

    Author : Mats Merup; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Advances in molecular genetics during the last decade has made it possible to identify genetic lesions in malignant cells that are specific for disease entities with a common clinical presentation and prognosis. In chronic lymphocytic leukemia (CLL) deletions in 13ql4 are the most frequently occurring abnormalities and deletions cluster around marker D13S319 suggesting that a tumor suppressor gene is located in this region. READ MORE