Search for dissertations about: "Cytologi"

Showing result 16 - 20 of 111 swedish dissertations containing the word Cytologi.

  2. 16. Pathophysiology of 5-fluorouracil induced cardiotoxicity : a clinical and experimental study

    Author : Magdalena Cwikiel; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; cell culture.; scanning and transmission electron microscopy; endothelium; lipid peroxidation; free radical; fibrinogen; 5-fluorouracil; blood and plasma viscosity; cardiotoxicity; cancerology; Cytologi; onkologi; cancer; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : This thesis concerns the pathophysiology of 5-fluorouracil (5-FU) induced cardiotoxicity. The aim of the clinical studies was to determine whether hemorheological factors might explain 5-FU cardiotoxicity (I) and if the syndrome was associated with free radical (FR) generation and lipid peroxidation (II). READ MORE

  4. 17. Development of adenoviral vectors for monitoring telomerase activity in living cells

    Author : Anna Edqvist; Neurokirurgi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; cytogenetics; Genetics; cancer; onkologi; Cytologi; cancerology; oncology; Cytology; GBM; HSC; adenovirus; hTERT; Genetik; cytogenetik;

    Abstract : ABSTRACT Telomerase activity is a potential molecular marker for cancer and primitive cells in regenerative tissues. The most commonly used method to measure telomerase activity in cells is the telomerase reverse amplification protocol (TRAP) assay, where the protein extracts derived from homogenized cells are analysed. READ MORE

  5. 18. Neuroblastoma Cell Differentiation: The Role of Neurotrophin Receptor Signaling and N-myc Expression

    Author : Anders Edsjö; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytologi; onkologi; cancer; oncology; cancerology; Cytology; N-myc.; trkC; trkB; trkA; neurotrophins; Neuroblastoma; sympathetic nervous system;

    Abstract : Neuroblastoma is a tumor of sympathetic nervous system derivation, mostly afflicting young children. This thesis is focused on a group of receptor proteins for neurotrophic factors, the Trk family, and on N-Myc, a transcription factor, all important in the formation of the sympathetic nervous system as well as in determining neuroblastoma patient outcome. READ MORE

  6. 19. Transcriptional analysis of mantle cell lymphoma - a global search for cellular origin and therapeutic targets

    Author : Sara Ek; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; oncology; cancerology; Cytologi; onkologi; Cytology; somatic mutation; microarray; tumour; mantle cell lymphoma; B cell;

    Abstract : This thesis is based upon four original papers describing the characterisation of mantle cell lymphoma (MCL) tumours and cell lines in comparison with different populations of normal B cells. Gene expression profiling, which were used in the studies, has during recent years developed as an important tool in characterisation of different types of malignancies. READ MORE

  7. 20. Cyclin A1 Expression and Regulation in Hematopoietic and Leukemic Cells

    Author : Jenny Ekberg; Malmö Patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; General pathology; pathological anatomy; Patologi allmän ; patologisk anatomi; onkologi; Cytologi; cancerology; oncology; Cytology; AML; cyclin A1; apoptosis; cell cycle regulation;

    Abstract : Increased expression of the cell cycle regulatory protein cyclin A1 has previously been detected in patients with acute myeloid leukemia (AML) and targeted overexpression of cyclin A1 in a transgenic mouse model initiated AML. The aim of this thesis was to further study the expression and regulation of cyclin A1 in hematopoietic cells. READ MORE