Search for dissertations about: "Cytotoxic-T-lymphocyte-associated antigen 4 CTLA-4"

Found 5 swedish dissertations containing the words Cytotoxic-T-lymphocyte-associated antigen 4 CTLA-4.

  2. 1. CTLA-4 expression, regulation and associations in autoimmune myasthenia gravis

    Author : XiongBiao Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cytotoxic-T-lymphocyte-associated antigen 4 CTLA-4 ; Myasthenia gravis MG ; Immune inhibitory receptor; Autoimmune disease; Genetic polymorphism.;

    Abstract : Myasthenia gravis (MG) is a neuromuscular disease with muscle weakness due to an autoimmune attack against the nicotinic acetylcholine receptor (nAChR) on the skeletal muscle endplate. Cytotoxic-T-lymphocyte-associated antigen 4 (CTLA-4) plays a global inhibitory role in the immune system and has a crucial role in autoimmunity. READ MORE

  4. 2. Functional studies of candidate genes contributing to type 1 diabetes in the NOD mouse

    Author : Marie Lundholm; Dan Holmberg; Vivianne Malmström; Umeå universitet; []
    Keywords : Type 1 Diabetes; NOD mouse; CTLA-4; Ctex; CD3ζ; apoptosis; Idd6; Lrmp; medicinsk genetik; Medical Genetics;

    Abstract : Type 1 Diabetes (T1D) is an autoimmune disorder caused by both genetic and environmental factors. The non-obese diabetic (NOD) mouse is one of the best and most commonly studied animal models for T1D. This mouse strain spontaneously develops diabetes through a process that closely resembles the human pathogenesis. READ MORE

  5. 3. Targeting innate and adaptive immune responses to achieve long-term allograft acceptance following transplantation

    Author : Ming Han Yao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Organ transplantation outcomes have gradually improved over the last 50 years. The development of more effective immunosuppressive drugs has been a major contributor to this improvement. READ MORE

  6. 4. Immune profile from high-risk to onset of Type 1 diabetes

    Author : Anna Rydén; Maria Faresjö; Johnny Ludvigsson; Malin Flodström-Tullberg; Linköpings universitet; []
    Keywords : ;

    Abstract : Type 1 diabetes (T1D) is most often diagnosed early in life and is usually the result of an autoimmune attack on the insulin producing β-cells of the pancreas, leading to a lack of insulin secretion and life-long insulin treatment. The search for possible targets pin-pointing the β-cell destruction is a constant endeavour in the pursuit to prevent T1D onset. READ MORE

  7. 5. T cells and costimulatory factors in myasthenia gravis

    Author : Maria Kakoulidou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : T cells; Myasthenia gravis MG ; costimulation; autoimmune disease; genetic polymorphism; twin;

    Abstract : The autoimmune disease myasthenia gravis (MG) is characterized by muscle weakness due to a loss of acetylcholine receptors (AChR) at the neuromuscular end plate. Most MG patients have pathogenic antibodies directed against the receptor. We provide further evidence that T cells are important for establishment and continuation of the disease. READ MORE