Search for dissertations about: "Cytotoxic-T-lymphocyte-associated antigen 4 CTLA-4"
Found 5 swedish dissertations containing the words Cytotoxic-T-lymphocyte-associated antigen 4 CTLA-4.
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1. CTLA-4 expression, regulation and associations in autoimmune myasthenia gravis
Abstract : Myasthenia gravis (MG) is a neuromuscular disease with muscle weakness due to an autoimmune attack against the nicotinic acetylcholine receptor (nAChR) on the skeletal muscle endplate. Cytotoxic-T-lymphocyte-associated antigen 4 (CTLA-4) plays a global inhibitory role in the immune system and has a crucial role in autoimmunity. READ MORE
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2. Functional studies of candidate genes contributing to type 1 diabetes in the NOD mouse
Abstract : Type 1 Diabetes (T1D) is an autoimmune disorder caused by both genetic and environmental factors. The non-obese diabetic (NOD) mouse is one of the best and most commonly studied animal models for T1D. This mouse strain spontaneously develops diabetes through a process that closely resembles the human pathogenesis. READ MORE
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3. Targeting innate and adaptive immune responses to achieve long-term allograft acceptance following transplantation
Abstract : Organ transplantation outcomes have gradually improved over the last 50 years. The development of more effective immunosuppressive drugs has been a major contributor to this improvement. READ MORE
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4. Immune profile from high-risk to onset of Type 1 diabetes
Abstract : Type 1 diabetes (T1D) is most often diagnosed early in life and is usually the result of an autoimmune attack on the insulin producing β-cells of the pancreas, leading to a lack of insulin secretion and life-long insulin treatment. The search for possible targets pin-pointing the β-cell destruction is a constant endeavour in the pursuit to prevent T1D onset. READ MORE
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5. T cells and costimulatory factors in myasthenia gravis
Abstract : The autoimmune disease myasthenia gravis (MG) is characterized by muscle weakness due to a loss of acetylcholine receptors (AChR) at the neuromuscular end plate. Most MG patients have pathogenic antibodies directed against the receptor. We provide further evidence that T cells are important for establishment and continuation of the disease. READ MORE