Search for dissertations about: "D-optimal design"

Showing result 1 - 5 of 8 swedish dissertations containing the words D-optimal design.

  1. 1. Experimental Designs at the Crossroads of Drug Discovery

    University dissertation from Umeå : Kemi

    Author : Ing-Marie Olsson; Umeå universitet.; [2006]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; Design of experiments; Experimental design; Multivariate data-analysis; D-optimal design; 96-well technology; Drug discovery; Assay optimisation; QSAR; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Abstract : New techniques and approaches for organic synthesis, purification and biological testing are enabling pharmaceutical industries to produce and test increasing numbers of compounds every year. Surprisingly, this has not led to more new drugs reaching the market, prompting two questions – why is there not a better correlation between their efforts and output, and can it be improved? One possible way to make the drug discovery process more efficient is to ensure, at an early stage, that the tested compounds are diverse, representative and of high quality. READ MORE

  2. 2. Optimal Design of Experiments for the Quadratic Logistic Model

    University dissertation from Stockholm : Department of Statistics, Stockholm University

    Author : Ellinor Fackle Fornius; Stockholms universitet.; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Logistic regression; D-optimality; c-optimality; Canonical design space; Maximum likelihood estimation; Sequential design; Stochastic approximation; SOCIAL SCIENCES Statistics; computer and systems science Statistics; SAMHÄLLSVETENSKAP Statistik; data- och systemvetenskap Statistik; statistik; Statistics;

    Abstract : Optimal design of experiments for binary data is the topic of this thesis. A particular logistic model including a quadratic term in the linear predictor is considered. Determining an optimal design for this model is complicated by the fact that the optimal design is dependent on the unknown true parameters. READ MORE

  3. 3. Computational Diffusion MRI: Optimal Gradient Encoding Schemes

    University dissertation from Stockholm : Department of Statistics, Stockholm University

    Author : Mohammad Alipoor; [2016]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Gradient Encoding Scheme; ADC imaging; Diffusion MRI; D-optimal experiment design; Diffusion Tensor Imaging; Optimal Image acquisition; Second and Fourth Order Tensors.; Diffusion Kurtosis Imaging;

    Abstract : Diffusion-weighted magnetic resonance imaging (dMRI) is a non-invasivestructural imaging technique that provides information about tissue microstructures.Quantitative measures derived from dMRI reflect pathologicaland developmental changes in living tissues such as human brain. READ MORE

  4. 4. Benefits of Non-Linear Mixed Effect Modeling and Optimal Design Pre-Clinical and Clinical Study Applications

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Charles Ernest II; Uppsala universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; optimal design; nonlinear mixed effects models; population models; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : Despite the growing promise of pharmaceutical research, inferior experimentation or interpretation of data can inhibit breakthrough molecules from finding their way out of research institutions and reaching patients. This thesis provides evidence that better characterization of pre-clinical and clinical data can be accomplished using non-linear mixed effect modeling (NLMEM) and more effective experiments can be conducted using optimal design (OD). READ MORE

  5. 5. Nonlinear Mixed Effects Methods for Improved Estimation of Receptor Occupancy in PET Studies

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Matts Kågedal; Uppsala universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PET; positron emission tomography; receptor occupancy; nonlinear mixed effects; NONMEM; optimal design; dose finding; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : Receptor occupancy assessed by Positron Emission Tomography (PET) can provide important translational information to help bridge information from one drug to another or from animal to man. The aim of this thesis was to develop nonlinear mixed effects methods for estimation of the relationship between drug exposure and receptor occupancy for the two mGluR5 antagonists AZD9272 and AZD2066 and for the 5HT1B receptor antagonist AZD3783. READ MORE