Search for dissertations about: "D. Scott Wilbur"

Found 2 swedish dissertations containing the words D. Scott Wilbur.

  2. 1. Radiohalogenated Compounds for Tumor Targeting : Synthesis and Radiolabeling

    Author : Eskender Mume; Stefan Sjöberg; Vladimir Tolmachev; D. Scott Wilbur; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Inorganic chemistry; 9-Aminoacridine; Daunorubicin; Doxorubicin; Carborane; Radiobromination; Radioiodination; Affibody; Monoclonal antibody; Oorganisk kemi; Inorganic chemistry; Oorganisk kemi;

    Abstract : This thesis describes the synthesis and radiohalogenation of compounds of potential use for tumor targeting. The first section describes the synthesis and radioiodination of DNA intercalating compounds. The compounds are derivatives of 9-aminoacridine, and the anthracyclins daunorubicin and doxorubicin. READ MORE

  4. 2. Indirect Radiohalogenation of Targeting Proteins : Labelling Chemistry and Biological Characterisation

    Author : Anna Orlova; Hans Lundqvist; Jörgen Carlsson; Lars Gedda; Jacek Capala; D.Scott Wilbur; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; radiohalogenation; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Biomedical Radiation Science; biomedicinsk strålningsvetenskap;

    Abstract : In about half of all newly diagnosed cancer cases, conventional treatment is not adequately curative, mainly due to the failure of conventional techniques to find and kill residual cells and metastases, which might consist of only a few malignant cells, without causing unacceptable complications to healthy tissue. To solve the problem a more selective delivery of cytotoxic substances to tumour cells is needed. READ MORE