Search for dissertations about: "D1"

Showing result 21 - 25 of 196 swedish dissertations containing the word D1.

  2. 21. Selectivity of dopamine D1 and D2 receptor agonists – A combined computational approach

    Author : Marcus Malo; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; dopamine; agonists; GPCRs; pharmacophore modeling; protein structure modeling; agonist selectivity;

    Abstract : Dopamine (DA) is an endogenous neurotransmitter acting in the central nervous system. DA plays a key role in many vital brain functions such as behavior, cognition, motor activity, learning, and reward. Dopamine receptors belong to the rhodopsin like family of G-protein coupled receptors (GPCRs). READ MORE

  4. 22. TISSUE MICROARRAY PERSPECTIVES ON CYCLIN D1 IN BREAST CANCER: Progression, prognosis and prediction

    Author : Karin Jirström; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pathological anatomy; General pathology; tamoxifen resistance; CCND1; Breast cancer; tissue microarrays; Patologi allmän ; patologisk anatomi;

    Abstract : Breast cancer is a truly heterogenous disease, reflected in the existence of a wide spectrum of phenotypic subsets of tumours with varying intrinsic aggressiveness as well as ability to respond to a given treatment. Recent advances in large-scale genomic and proteomic screening techniques have confirmed this heterogeneity also at a molecular level, but there is still a bottleneck to be overcome before the discoveries in the laboratory can be translated into the much more complex clinical situation in order to develop better targeted therapies. READ MORE

  5. 23. On the mechanism and consequences of light-induced D₁ protein degradation in higher plants

    Author : Ivar Virgin; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; biokemi; Biochemistry;

    Abstract : The basic source of energy for the whole biosphere is sunlight which is converted tochemical energy by the process of photosynthesis in a wide variety of organisms rangingfrom prokaryotic bacteria to eukaryotic higher plants. It is therefore surprising thatphotosynthetic activity can be reduced when plants are exposed to excessive light,especially under adverse environmental conditions. READ MORE

  6. 24. Characterization of dopamine D1 receptor agonists in vivo : implications for the treatment of schizophrenia and Parkinson's disease

    Author : Ruben Isacson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Dopamine is fundamental in human behavior for movement, cognition and reward. A dysfunctional dopamine system is implicated in several neurological and psychiatric disorders such as Parkinson s disease and schizophrenia. Dopamine mediates its effects through five receptors. READ MORE

  7. 25. The biological role and clinical impact of SYT-SSX fusion gene and IGF-1R in synovial sarcoma

    Author : Yuntao Xie; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Synovial sarcoma; translocation; SYT-SSX; IGF-1R cyclin D1; cell cycle; proliferation; apoptosis.;

    Abstract : Synovial sarcoma, which is a highly malignant soft tissue tumour occurring mainly in young and middle-aged adults, is characterized by the translocation t(X; 18)(p 11.2; q 11.2). READ MORE