Search for dissertations about: "D2 receptor"

Showing result 1 - 5 of 124 swedish dissertations containing the words D2 receptor.

  2. 1. Population Pharmacodynamic Modeling and Methods for D2-receptor Antagonists

    Author : Klas Petersson; Lena Friberg; Mats Karlsson; An Vermeulen; Robert Bies; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; population modeling; schizophrenia; D2-antagonists; pharmacodynamics; drug development;

    Abstract : Early predictions of a potential drug candidate’s time-course of effect and side-effects, based on models describing drug concentrations, drug effects and disease progression, would be valuable to make drug development more efficient. Pharmacodynamic modeling can incorporate and propagate prior knowledge and be used for simulations of different scenarios. READ MORE

  4. 2. Development of novel serotonin 5-HT6 and dopamine D2 receptor ligands and MAO A inhibitors - Synthesis, structure-activity relationships and pharmacological characterization

    Author : Cecilia Mattsson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; dopamine D2 receptor; serotonin reuptake transporter; monoamine oxidase; 5-HT6 receptor; DOPAC; 5-HIAA; 3-tetrahydropyridine indole; 3-piperidine indole; 3- pyrrolidin-1-ylmethyl chromen-2-one; dopamine D2 receptor;

    Abstract : It is known since the 1950s that enhancement of the levels of the monoamines dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) in the brain will relieve the symptoms of major depression, and current therapies are still based on this mechanism. However, all available antidepressants today are still suffering from slow onset of therapeutic action, as well as adverse effects and lack of efficacy. READ MORE

  5. 3. Dopamine D2 and D3 receptor-ligand interactions : molecular pharmacology and medicinal chemistry

    Author : Åsa Malmberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  6. 4. Adenosine receptor/dopamine receptor interactions : molecular and biochemical aspects

    Author : Maria Torvinen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adenosine; adenosine deaminase; A; receptor; A2A receptor; cell line; coimmunoprecipitation; confocal microscopy; dopamine; D1 receptor; D2 receptor; D3 receptor; heteromerization; internalisation; radioligand binding;

    Abstract : The dopamine receptors have been shown to be involved in a variety of higher brain functions, such as motor control, cognition and affective states. Agonist and antagonists of dopamine receptors are widely used to treat disorders such as Parkinson's disease and schizophrenia, respectively. READ MORE

  7. 5. Dopamine D2 and D3 receptors. Studies on transduction mechanisms and on the role of a D3 gene polymorphism

    Author : Monika Hellstrand; Göteborgs universitet; []
    Keywords : dopamine; dopamine D2 receptor; dopamine D3 receptor; transduction; CHO cells; partial agonism; inverse agonism; arachidonic acid; prostaglandin E2; cAMP; haloperidol; -3-PPP; PNU-99194A; polymorphism; personality;

    Abstract : The neurotransmitter dopamine has been implicated in the pathophysiology of, e.g., Parkinson s disease and schizophrenia, and dopamine receptor-active compounds are commonly employed therapeutically in these and other disorders. READ MORE