Search for dissertations about: "DAP12"
Showing result 1 - 5 of 10 swedish dissertations containing the word DAP12.
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1. Regulation of NK cell activity : studies of DAP12-associated receptors in immune synapse formation and in responses to cytomegalovirus infection
Abstract : Natural killer (NK) cell effector functions are important for innate resistance against tumor cells and viral infections. NK cells display a broad range of inhibitory and activating receptors on the cell surface, which ensure specificity. READ MORE
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2. TRAPC : a novel triggering receptor expressed on antigen presenting cells
Abstract : The triggering receptor expressed on myeloid cells (TREM) family of receptors plays an important role in innate immunity. They have been described to regulate the course of sepsis, DC maturation, bone modulation and microglial function, and as markers for bacterial infections. READ MORE
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3. Diabetes pathogenesis : role of natural killer cells, T cells and a novel neuropeptide
Abstract : Diabetes is a major health problem affecting nearly 5% of the population world wide. It is a heterogeneous group of diseases with the autoimmune type 1 diabetes (T1D) and the metabolic type 2 diabetes (T2D) being the major types. READ MORE
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4. Macrophage antigen expression in breast and colorectal cancers : A consequence of macrophage - tumour cell fusion?
Abstract : Carcinogenesis is a sophisticated biological process consisting of a series of progressive changes in somatic cells from premalignant to malignant phenotype. Despite the vast information available about cancer cells, the origin of cancer and cause of metastasis still remain enigmatic. READ MORE
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5. NK cell recognition : adaptability to host factors in normal and diabetic mice
Abstract : The overall aim of this thesis was to understand the rules, which guide NK cell behavior in vivo. NK cells are part of the innate immune system and are important in defense against certain virus infections and tumorigenic cells. They also play a role in rejecting bone marrow grafts. READ MORE